Developments and ongoing challenges for analysis of surface-bound proteins
T Weidner, DG Castner - Annual Review of Analytical Chemistry, 2021 - annualreviews.org
… This article describes radiolabeling, surface plasmon resonance, … Technical improvements
(near-total internal reflection … ability to sequence and identify large surface-bound proteins. …
(near-total internal reflection … ability to sequence and identify large surface-bound proteins. …
Labeling single domain antibody fragments with 18F using a novel residualizing prosthetic agent—N-succinimidyl 3-(1-(2-(2-(2-(2-[18F] fluoroethoxy) ethoxy) ethoxy) …
Z Zhou, D McDougald, R Meshaw… - Nuclear medicine and …, 2021 - Elsevier
… 4 h, cell culture supernatants were removed, surface-bound activity was stripped from the …
to 5F7, which does internalize extensively. While this difference may be a factor influencing …
to 5F7, which does internalize extensively. While this difference may be a factor influencing …
Application of quantitative protein mass spectrometric data in the early predictive analysis of membrane-bound target engagement by monoclonal antibodies
A Sepp, M Muliaditan - Mabs, 2024 - Taylor & Francis
… target complexes undergo cellular internalization and degradation … Target receptor (brown
structure) exists in surface-bound and … First of all, despite a 25- to 50-fold difference in receptor …
structure) exists in surface-bound and … First of all, despite a 25- to 50-fold difference in receptor …
Pharmacokinetics and tumor delivery of nanoparticles
… dendrimers can be internalized as short as 20 min [43]. … to the NPs via the surface bound
opsonins. In addition, non-… and differences in permeability of blood vessels can cause a low …
opsonins. In addition, non-… and differences in permeability of blood vessels can cause a low …
[HTML][HTML] The solute carrier SLC7A1 may act as a protein transporter at the blood-brain barrier
M Kurtyka, F Wessely, S Bau, E Ifie, L He… - … Journal of Cell Biology, 2024 - Elsevier
… that SLC7A1 internalised a SLC7A1-specific antibody in … The aim of our study was to identify
and validate novel candidate … and PBS pH 2 to dissociate surface-bound antibodies. Next, …
and validate novel candidate … and PBS pH 2 to dissociate surface-bound antibodies. Next, …
Development of Novel Trifunctional Chelating Agents That Enhance Tumor Retention of Radioimmunoconjugates
K Nakashima, H Watanabe, M Ono - Journal of Medicinal …, 2023 - ACS Publications
… tendency of the cell surface-bound radioactivity to reside in tumor cells or leave the cells, the
ratio of the internalized radioactivity to … To separate the cell surface-bound radioactivity and …
ratio of the internalized radioactivity to … To separate the cell surface-bound radioactivity and …
The biodistribution of therapeutic proteins: Mechanism, implications for pharmacokinetics, and methods of evaluation
KP Conner, SC Devanaboyina, VA Thomas… - Pharmacology & …, 2020 - Elsevier
… , or help to identify off-target tissues at risk for increased TP … antibody/fragment as an IgG
isotype/class-matched internal … However, for the sake of brevity we will limit our discussion of …
isotype/class-matched internal … However, for the sake of brevity we will limit our discussion of …
Recent developments in cancer therapy and diagnosis
… , radiolabeled vasoactive intestinal peptides are used to … targeting and internalization. They
change their structures to … (CTLs) can recognize and kill tumor cells expressing HER2. While …
change their structures to … (CTLs) can recognize and kill tumor cells expressing HER2. While …
Radiolabeled gold nanoseeds decorated with substance P peptides: synthesis, characterization and in vitro evaluation in glioblastoma cellular models
F Silva, A D'Onofrio, C Mendes, C Pinto… - International Journal of …, 2022 - mdpi.com
… lower cellular internalization with a maximum internalization … Remarkable differences were
observed for the radiobiological … to the cell–surface bound radioactivity was collected. The …
observed for the radiobiological … to the cell–surface bound radioactivity was collected. The …
Development of a New Class of CXCR4-Targeting Radioligands Based on the Endogenous Antagonist EPI-X4 for Oncological Applications
RH Gaonkar, YT Schmidt, R Mansi… - Journal of Medicinal …, 2023 - ACS Publications
… difference among them. Radiolysis can be possibly diminished with the use of radiolytic
scavengers after or during radiolabeling. … -specific cell surface-bound and internalization kinetics …
scavengers after or during radiolabeling. … -specific cell surface-bound and internalization kinetics …