[HTML][HTML] Advances in protein-protein interaction network analysis for Parkinson's disease

JE Tomkins, C Manzoni - Neurobiology of Disease, 2021 - Elsevier
… PPI network with the ORFs located in different linkage disequilibrium … of high-quality proteomics
and genomics data opens the … (linked to disease risk) and changes in protein expression …

Revealing protein-protein interactions at the transcriptome scale by sequencing

KL Johnson, Z Qi, Z Yan, X Wen, TC Nguyen… - Molecular cell, 2021 - cell.com
… by our understanding of the interaction networks formed by the … proteome-scale map of the
human protein-protein interaction … translated protein from this mRNA is then covalently linked

Stitching the synapse: Cross-linking mass spectrometry into resolving synaptic protein interactions

MA Gonzalez-Lozano, F Koopmans, PF Sullivan… - Science …, 2020 - science.org
… In terms of PPIs, we generated an XL-based protein interaction network … Comparing our
cross-linking data with the accumulated … abundances were obtained from our previous proteomic

[HTML][HTML] Comparison of path-based centrality measures in protein-protein interaction networks revealed proteins with phenotypic relevance during adaptation to …

M Gilbert, Z Li, XN Wu, L Rohr, S Gombos, K Harter… - … of proteomics, 2021 - Elsevier
… Individual interactions within the reconstructed network were … in protein-protein interaction
networks based on their network … to nodes that connect different network communities. In this …

An atlas of protein-protein interactions across mouse tissues

MA Skinnider, NE Scott, A Prudova, CH Kerr… - Cell, 2021 - cell.com
… organization of proteins in networks of physical interactions. Mapping … However, the dynamics
of protein interactions across … efforts to profile the transcriptome, proteome, and epigenome …

Mass spectrometry‐based proteinprotein interaction networks for the study of human diseases

AL Richards, M Eckhardt, NJ Krogan - Molecular systems biology, 2021 - embopress.org
… combined with quantitative MS, allow the proteomelevel analysis of complex biological
systems. … , linking KRAS activity to a myriad of adaptive network alterations spanning from core …

A novel insight into neurological disorders through HDAC6 proteinprotein interactions

N Bahram Sangani, J Koetsier, J Mélius, M Kutmon… - Scientific Reports, 2024 - nature.com
… of our HDAC6 network, we mapped transcriptomics data of … here as a bridge that links
polyubiquitinated proteins (via its BUZ … Mapping the transcriptomics and proteomics data from drug …

Heterogeneous multi-layered network model for omics data integration and analysis

B Lee, S Zhang, A Poleksic, L Xie - Frontiers in genetics, 2020 - frontiersin.org
… as protein-protein interaction, … network model needs more than three layers to connect
genome to phenome via epigenome (DNA layer), transcriptome (RNA layer), proteome (protein

Proteomic and interactomic insights into the molecular basis of cell functional diversity

I Bludau, R Aebersold - Nature Reviews Molecular Cell Biology, 2020 - nature.com
… cell at the levels of the transcriptome, proteome and interactome (… and stable proteinprotein
interactions (PPIs) and protein … , including cross-linking the full proteome of Escherichia coli, …

Combined transcriptome and proteome profiling of the pancreatic β-cell response to palmitate unveils key pathways of β-cell lipotoxicity

M Lytrivi, K Ghaddar, M Lopes, V Rosengren, A Piron… - BMC genomics, 2020 - Springer
networks were inferred in the RNA-seq and proteomics data separately using a random forest
algorithm to score predictors and then the 2 networks … identified in proteomics and black …