The neuroprotective effects of alpha‐lipoic acid on an experimental model of Alzheimer's disease in PC12 cells
X Pei, F Hu, F Luo, X Huang, X Li… - Journal of Applied …, 2022 - Wiley Online Library
… AD is a progressive disease with a long duration, and the pathogenesis is very complicated.
Here, we found that alpha-lipoic acid (LA), an endogenous, naturally synthesized compound…
Here, we found that alpha-lipoic acid (LA), an endogenous, naturally synthesized compound…
Decrypting the potential role of α-lipoic acid in Alzheimer's disease
D Kaur, T Behl, A Sehgal, S Singh, N Sharma… - Life Sciences, 2021 - Elsevier
… the neuroprotective … lipoic acid (α-LA) is a naturally occurring agent in food with
antioxidizing, anti-apoptotic, metal chelating, glioprotective, carbonyl scavenging, and anti-inflammatory …
antioxidizing, anti-apoptotic, metal chelating, glioprotective, carbonyl scavenging, and anti-inflammatory …
Neuroprotective Effect of α-Lipoic Acid against Aβ25–35-Induced Damage in BV2 Cells
X Pei, F Hu, Z Hu, F Luo, X Li, S Xing, L Sun, D Long - Molecules, 2023 - mdpi.com
… with Alzheimer’s disease (AD). BV2 cells were divided into control, LA, Aβ 25–35 , and LA …
anti-inflammatory and antioxidant substances may offer a promising approach to the treatment …
anti-inflammatory and antioxidant substances may offer a promising approach to the treatment …
Enantioselective Synthesis and Pharmacological Evaluation of Aza-CGP37157–Lipoic Acid Hybrids for the Treatment of Alzheimer's Disease
Á Cores, P Michalska, JM Pérez, E Crisman, C Gómez… - Antioxidants, 2022 - mdpi.com
… lipoic acid were obtained in order to combine in a single molecule the antioxidant and NRF2
induction properties of lipoic acid and the neuroprotective … and anti-inflammatory activity [11]…
induction properties of lipoic acid and the neuroprotective … and anti-inflammatory activity [11]…
Natural molecules and neuroprotection: kynurenic acid, pantethine and α-lipoic acid
… to their neuroprotective effect, they are known for their antioxidant, anti-inflammatory and …
are discussed: firstly, kynurenic acid, the main neuroprotective agent formed via the kynurenine …
are discussed: firstly, kynurenic acid, the main neuroprotective agent formed via the kynurenine …
α-Lipoic acid, an organosulfur biomolecule a novel therapeutic agent for neurodegenerative disorders: an mechanistic perspective
… and anti-inflammatory agents, … lipoic acid (IBU-LA) treatment have the potential to keep a
high neuroglobin (Ngb) level in an AD model, enabling Ngb to perform either its neuroprotective …
high neuroglobin (Ngb) level in an AD model, enabling Ngb to perform either its neuroprotective …
Neuromodulatory mechanisms of a memory loss-preventive effect of alpha-lipoic acid in an experimental rat model of dementia
H Staykov, M Lazarova, Y Hassanova… - Journal of Molecular …, 2022 - Springer
… Alpha-lipoic acid (ALA) is a naturally occurring molecule with neuroprotective, anti-inflammatory,
metal-chelating and strong antioxidant properties. Data also show that it exerts …
metal-chelating and strong antioxidant properties. Data also show that it exerts …
Neuroprotective role of α-lipoic acid in iron-overload-mediated toxicity and inflammation in in vitro and in vivo models
G Carota, A Distefano, M Spampinato, C Giallongo… - Antioxidants, 2022 - mdpi.com
… Current available treatments for iron overload-mediated disorders are characterized by … of
α-lipoic acid (ALA) as an iron chelator, antioxidant and anti-inflammatory agent in both in vitro …
α-lipoic acid (ALA) as an iron chelator, antioxidant and anti-inflammatory agent in both in vitro …
Alpha lipoic acid ameliorates scopolamine induced memory deficit and neurodegeneration in the cerebello-hippocampal cortex
AE Memudu, AE Adewumi - Metabolic Brain Disease, 2021 - Springer
… α-lipoic acid due to its anti-oxidant and anti-inflammatory potentials. The control and α-lipoic
acid-treated … This demonstrates that α-lipoic acid can potentiate neuroprotection and reverse …
acid-treated … This demonstrates that α-lipoic acid can potentiate neuroprotection and reverse …
Enantioselective Synthesis and Pharmacological Evaluation of Aza-CGP37157–Lipoic Acid Hybrids for the Treatment of Alzheimer's Disease
Á Cores Esperón, P Michalska, JM Pérez, E Crisman… - 2022 - docta.ucm.es
… properties of lipoic acid and the neuroprotective activity of … contributing to its antioxidant and
anti-inflammatory activity [11]. … In search of an anti-inflammatory drug for Alzheimer disease. …
anti-inflammatory activity [11]. … In search of an anti-inflammatory drug for Alzheimer disease. …