… primary and metastatic castration resistant prostate cancer (… in the BMP53 rat model of
prostate cancer, which develops … to luminal cell death following castration (Kurita et al., 2001). …

… and rats were especially vital to the work in this dissertation. … mitotic figures, apoptotic cells,
and loss of basal cell layer. On … also used to treat castration resistant prostate cancer. ADT is …

… , body weight, or prostate apoptosis produced by castration and hormonal replacement. …
androgens. TNF is one of the main triggers of cell death and inflammation; hence, DU145 cells …

… in prostate weight was observed in T4-treated castrated rats (28… the prostatic metabolic
homeostasis in a lobe-specific manner. … apoptosis and reduces the invasive potential of prostate …

… Androgen deprivation therapy (ADT) is an effective therapy … neonatal prostatic buds are not
developed in pregnant female rats with … to inhibit apoptosis that are independent of androgen-…

… Androgen deprivation therapy (ADT) combined with radiotherapy is stan… castration results
in prostate atrophy due to apoptosis of … focused on both the whole prostate and lobespecific …

… the androgen axis Because androgens and AR play such a significant role in the prostate, …
used to treat CaP target this pathway by androgen deprivation therapy (ADT) via (1) surgical …

… Prostate cancer (PCa) is a disease that arises from cells in the prostate and in recent
years … strategies for advanced PCa such potent androgen receptor pathway inhibitors (ARPIs) …

… lobes of BN rats may be explained by the following mechanisms. … T, as AR levels remain
unchanged in castrated rats. In addition, … and inhibits prostate cell apoptosis. The results of the …

… of the prostatic acid phosphatase (ACPP) from rat prostate … ) of Bcl2-associated agonist
of cell death (BAD) [136]. … demonstrated in a castration-resistant PCa cell line in which in …