… of its catalytic activity and participates in multiple processes … the processes linking promoter
DNA methylation with gene … cancer stem cells of leukemia, pancreatic cancer, osteosarcoma, …

… Altogether, these findings suggest that SCD1 is a gatekeeper that protects β-cells against
the lipid-derived loss of DNA methylation and provide mechanistic insights into the mechanism …

… patterns of DNA methylation during cellular replication. … DNA methylation is catalyzed
by the enzymes DNA … , there is a lack of functional studies on DNMT1 in PanINs or …

… methyltransferases that have the catalytic activity, while Dnmt2 and Dnmt3l lack DNA … , and
loss of Dnmt1 in pancreatic progenitors leads to pancreatic atrophy. Specification of different …

… is abnormal DNA methylation, particularly hypermethylation of the … In mammal cells, DNA
methylation is catalyzed and … study revealed high levels of DNMT1 in pancreatic cancer tissues …

… in about 80% loss of the catalytic activity of the mutant … pancreatic cancer, DNMT1
hypomorphic mice had a reduction in tumor burden coupled with decreased DNA methylation at …

… of the methylation modifications in PC from DNA methylation, … which terminates due to the
lack of DNMT1. In general, … or III enzymes according to their catalytic activity. PRMT1 from type I …

… We also find that over-expression of HOXB9 inhibits pancreatic … CpG methylation is
catalyzed by DNA methyltransferases (… DNA methylation as a kind of epigenetic modification is …

… loss of DNA methylation leads to activation of p53 responses and/or the DDR. A study on
the role of DNMT1 in pancreatic … These mutations impair the catalytic activity of TET2 in vitro …

… function loss by 42 weeks of age 18,21,25,26 . In our results, … s pancreatic β-cells 20,21 .
Previously study have showed the importance of DNA methylation in pancreatic islet function 10 …