Stress affects central compensation of neural responses to cochlear synaptopathy in a cGMP-dependent way

D Savitska, M Hess, D Calis, P Marchetta… - Frontiers in …, 2022 - frontiersin.org
… A loss of afferent auditory fibers (cochlear synaptopathy) can … However, threshold sensitivity
in response to pure-tone … nerve response (ABR wave I), and inner hair cell ribbons, which we …

Detecting noise-induced cochlear synaptopathy by auditory brainstem response in tinnitus patients with normal hearing thresholds: A meta-analysis

F Chen, F Zhao, N Mahafza, W Lu - Frontiers in neuroscience, 2021 - frontiersin.org
… of synapses between the inner hair cells (IHCs) and auditory … , questioning the sensitivity
of wave I amplitude to detect CS. … central enhancement to compensate for reduced neural …

Current topics in hearing research: Deafferentation and threshold independent hearing loss

M Trevino, E Lobarinas - Hearing research, 2022 - Elsevier
… as a result of synaptopathy and/or inner hair cell loss. … inner hair cell damage, including loss
of afferent synapses, … understanding of auditory system plasticity and compensation. Results …

Contrasting mechanisms for hidden hearing loss: Synaptopathy vs myelin defects

M Budak, K Grosh, A Sasmal, G Corfas… - PLoS computational …, 2021 - journals.plos.org
… Studies on animal models suggest two possible pathogenic mechanisms for HHL: (1)
loss of synapses between inner hair cells and auditory nerve fibers, and (2) disruption of …

Inner hair cell synapse density influences auditory processing

L Ji, BC Borges, DT Martel, C Wu, MC Liberman… - bioRxiv, 2022 - biorxiv.org
… proposed that inner hair cell (IHC) synaptopathy, ie, loss of … reflecting homeostatic
compensation in the auditory brainstem … Loss of auditory sensitivity from inner hair cell

Auditory-nerve responses in mice with noise-induced cochlear synaptopathy

K Suthakar, MC Liberman - Journal of neurophysiology, 2021 - journals.physiology.org
… the increased sensitivity to rapid temporal-envelope modulations can be attributed … lack of
hair cell damage in the present study strongly suggests that improved temporal precision can

Loss of Pex1 in Inner Ear Hair Cells Contributes to Cochlear Synaptopathy and Hearing Loss

SA Mauriac, T Peineau, A Zuberi, C Lutz, GSG Géléoc - Cells, 2022 - mdpi.com
… To determine if compensation occurs in the VGlut3 Cre/Cre … Pex1 fl/fl mice compensate
centrally for the reduced cochlear … , would predict high sensitivity to noise induced hearing loss

[HTML][HTML] Disturbed balance of inhibitory signaling links hearing loss and cognition

M Knipper, W Singer, K Schwabe… - Frontiers in Neural …, 2022 - frontiersin.org
… responses as a stress-sensitive process. Ultimately, under … , spontaneous glutamate release
from inner hair cells (IHCs), … centrally compensate age-dependent cochlear synaptopathy

[PDF][PDF] Deciphering compromised speech-in-noise intelligibility in older listeners: the influence of cochlear synaptopathy

M Garrett, V Vasilkov, M Mauermann, JL Wilson… - bioRxiv, 2020 - scholar.archive.org
… role of synaptopathy and hearing sensitivity for speech … ent synapses between hair cells
and auditory-nerve bers … compensate for the functional consequences of synaptopathy. …

Age-dependent auditory processing deficits after cochlear synaptopathy depend on auditory nerve latency and the ability of the brain to recruit LTP/BDNF

P Marchetta, D Savitska, A Kübler, G Asola, M Manthey… - Brain Sciences, 2020 - mdpi.com
… of auditory nerve fibers from hair cells (cochlear synaptopathy… that cochlear synaptopathy,
if centrally compensated through … who have maintained good hearing sensitivity, nevertheless …