… translation initiation in the absence of cellular initiation factors, making it possible to more
directly assess the contribution … ; our MCF10A DKC1 OE and CTRL cells were transfected with …

… from MCF10A DKC1 overexpressing and control cells for their translation efficiency. We …
Loss of function of the tumor suppressor DKC1 perturbs p27 translation control and contributes …

… Maintenance of the proper conformation of the three anticodon residues helps foster correct
… in p27 expression. Therefore, DKC1 is a tumor suppressor that controls translation by its …

… DKC1 acts as a tumour suppressor and inhibits the development of pituitary tumours by
downregulating the translational level of p27… DKC1 stable knockdown or HIF-1α rescue or control …

… which I believe this project contributes to achieve its global goal … The protein p27 acts as a
tumour suppressor, however, it has … showed DKC1 reduced p27 IRES-dependent translation. …

… Loss of dyskerin dysregulates initiation of translation of tumour suppressor proteins such as
p53 and p27 … , the observed loss of dyskerin in endometrial cancer tissue may contribute to …

… advantage of translation regulation that helps tumor cells adapt … for rRNA modifications
(eg, DKC1, which catalyzes pseudo-… the translation repression of these tumor suppressors in …

… we discuss the roles of Ψ in basic RNA biology, the emerging contributions of Ψ to cancer
and … The importance of Ψ in translation is reflected by its widespread distribution, influencing …

… RNA substrates and thereby contribute to RNA surveillance. … mRNAs undergoing premature
translation termination due to … with DKC1, we decided to superimpose the SMUG1–DKC1 …

… recent contributions linking rRNA modifications to translation … switch is largely impaired in
patients harboring DKC1 mutations, … elements, such as the tumor suppressor p27 kip1 [43] and …