[HTML][HTML] Human umbilical cord mesenchymal stem cells-derived exosomes exert anti-inflammatory effects on osteoarthritis chondrocytes

S Wang, W Jiang, S Lv, Z Sun, L Si, J Hu… - Aging (Albany …, 2023 - ncbi.nlm.nih.gov
… And then, chondrocytes were stained with In Situ Cell Death … inhibition of inducible nitric
oxide synthase is preferred as a … mTOR and NF-κB serve as master modulators responsible for …

Genetic and Epigenetic Insights into Osteoarthritis Pathogenesis; Spotlighting STAT3 and miR-452-3p as Illuminating Examples

DA Mohamed, AS Wahba, ET Mehanna… - Records of …, 2024 - journals.ekb.eg
… Similarly, the CpG sites within the promoter area of a number of MMPs, … into the nucleus
and activates the expression of NF-κB … -2 (COX2), Inducible nitric oxide synthase (iNOS), IL-6 …

DNA methylation as a mediator of epigenetic regulation in the pathogenesis and precision medicine of osteoarthritis: An updated review.

Q Zhou, J Liu, L Xin, Y Fang, L Wan, D Huang… - …, 2023 - search.ebscohost.com
… deteriorated cartilage and 1,397 differentially methylated CpG sites in … Loss of methylation
in CpG sites in the NF-κB enhancer elements of inducible nitric oxide synthase is responsible

Osteoarthritis treatment with a novel nutraceutical acetylated ligstroside aglycone, a chemically modified extra-virgin olive oil polyphenol

MC de Andrés, MS Meiss… - Journal of tissue …, 2020 - journals.sagepub.com
nitric oxide release; and, importantly, reduced proteoglycan … and downregulating NF-κB
as well as the potential to induce a … due to hypomethylation at CpG sites which may be itself …

[HTML][HTML] Nutraceutical activity in osteoarthritis biology: a focus on the nutrigenomic role

S D'Adamo, S Cetrullo, V Panichi, E Mariani… - Cells, 2020 - mdpi.com
… drive the loss of maturational arrest via activation of NF-κB pathway [… NF-κB activation leads
to increased expression of known targets, such as COX-2 and inducible nitric oxide synthase

Epigenetic Regulation of Autophagy in Bone Metabolism

Y Zhang, Q Wang, H Xue, Y Guo, S Wei, F Li, L Gong… - Function, 2024 - academic.oup.com
… pathways like MAPK and 39 NF-κB during this process 158. … species (ROS), IL-1β, nitric
oxide (NO), Fas, 34 and tumor … with IL-1β leads to decreased 31 methylation at CpG sites in …

[PDF][PDF] DNA methylation as a mediator of epigenetic regulation in the pathogenesis and precision medicine of osteoarthritis: An updated

Q ZHOU, J LIU, L XIN, Y FANG, LEI WAN, DAN HUANG… - cdn.techscience.cn
… deteriorated cartilage and 1,397 differentially methylated CpG sites in … Loss of methylation
in CpG sites in the NF-κB enhancer elements of inducible nitric oxide synthase is responsible

[HTML][HTML] The role of genetics and epigenetic regulation in the pathogenesis of osteoarthritis

K Kiełbowski, M Herian, E Bakinowska… - International Journal of …, 2023 - mdpi.com
… IL-6, which is enriched in CpG sites, is hypomethylated in SF … Similar results were observed
in the levels of nitric oxide and … through the interaction with components of NF-κB at the MMP…

[HTML][HTML] Overview of MMP-13 as a promising target for the treatment of osteoarthritis

Q Hu, M Ecker - International journal of molecular sciences, 2021 - mdpi.com
… toward a net loss of cartilage [18]. The breakdown products of … -chain-enhancer of activated
B cells (NF-κB), phosphoinositide 3-… showed that methylation of the −110 bp CpG site, which …

[HTML][HTML] Current understanding of osteoarthritis pathogenesis and relevant new approaches

L Tong, H Yu, X Huang, J Shen, G Xiao, L Chen… - Bone research, 2022 - nature.com
… Next, we discuss the timely updates concerning cell death … (SOD2) and inducible nitric
oxide synthase (iNOS)]. DNA … NF-κB pathway, as well as Mmp13 and Adamts5 expression, …