… steps for the understanding the roles of DNA damage repair in the … DNA damage repair
associated with targeted cancer therapy, highlighting the specific proteins behind targeting DNA …

… of the DNA ligase IV complex that allows NHEJ, MRX(N) … by resection, (ii) the homologous
DNA pairing, which requires … of the cell cycle is sufficient to induce cohesin enrichment in the …

Nicotinamide adenine dinucleotide (NAD + ) and its metabolites function as critical regulators
to maintain physiologic processes, enabling the plastic cells to adapt to environmental …

… cell cycle arrest and provide sufficient time for DNA repair [12, 13]… blot, radiate in 5 Gy for 4
h. E qRT-PCR detected the mRNA … It is reported that LIG4, a DNA ligase in DNA double-strand …

… depletion of DNA PKcs- and DNA ligase 4, two important components of NHEJ, was sufficient
to … Three days later, cells were washed three times with PBS and supplemented with fresh …

… other DNA repair factors, including XRCC1 and DNA Ligase 3… from one allele is sufficient
to abrogate murine embryonic … to rule out minor impacts on HR and NHEJ in the Parp1 +/A …

… another key player in NHEJ. A protein called artemis cleaves damaged ends of DNA to allow
DNA ligase IV (LigIV) … Of the three main proteins involved in ligation in the NHEJ pathway, …

… Ionizing radiation (IR), as the name indicates carry sufficient … DNA Ligase IV rejoins one
strand of DNA at a time and … θ that is sealed by DNA ligase I or DNA ligase III. Apart from these …

… This physical juxtaposition of DNA ends is called NHEJ … /Cy5-labeled short duplex using T4
DNA ligase (Millipore Sigma, … key NHEJ proteins, Ku, X4L4 and XLF, are sufficient to mediate …

… An alternative NHEJ (altNHEJ) pathway also exists, which relies on the XRCC1–DNA ligase
III … We found that hypotonic treatment is sufficient to induce over-accumulation of GFP-Ku70, …