Emerging functions of tissue-resident eosinophils

A Gurtner, D Crepaz, IC Arnold - Journal of Experimental Medicine, 2023 - rupress.org
… adaptation to distinct niches. The GI tract further harbored two distinct eosinophil subsets—…
Resolution of arthritis was associated with the emergence of a regulatory eosinophil subset

Blood and adipose-resident eosinophils are defined by distinct transcriptional profiles

M Shah, AJ Knights, EJ Vohralik… - Journal of Leukocyte …, 2023 - academic.oup.com
… gene regulatory mechanisms that allow eosinophils to … given that these are all subsets of
eosinophils. Interestingly, the … tissue eosinophil function is controlled by a distinct transcriptional …

[HTML][HTML] Mouse resident lung eosinophils are dependent on IL‐5

A Dolitzky, S Grisaru‐Tal, S Avlas, I Hazut, Y Gordon… - Allergy, 2022 - ncbi.nlm.nih.gov
… Siglec‐F, is regulated by IL‐5 drawing caution to previous conclusions. … that distinct eosinophil
populations in the asthmatic lung … of activation states rather than different cellular subsets. …

The multiple functions and subpopulations of eosinophils in tissues under steady-state and pathological conditions

A Kanda, Y Yun, D Van Bui, LM Nguyen… - Allergology …, 2021 - jstage.jst.go.jp
… , eosinophils exert tissue damage through eosinophilderived … of distinct different
subpopulations of eosinophils between … Collectively, those results indicate that eosinophil-regulated

Heterogeneity of intestinal tissue eosinophils: potential considerations for next-generation eosinophil-targeting strategies

JC Masterson, C Menard-Katcher, LD Larsen… - Cells, 2021 - mdpi.com
distinct eosinophil subtypes within the lung, Percopo etal. identified a small Gr1 hi -expressing
subset of lung eosinophils … Beyond regulating eosinophil recruitment, periostin supports α …

… biological aspects of eosinophils in host defense, eosinophil-associated diseases, immunoregulation, and homeostasis: is their role beneficial, detrimental, regulator …

A Kanda, Y Yasutaka, D Van Bui, K Suzuki… - Biological and …, 2020 - jstage.jst.go.jp
eosinophil subtypes, it has been shown that resident and phenotypically distinct eosinophils
inflammation may play an important role in this subset of patients.In adipose tissue, AAMs …

Helminth infection induces a distinct subset of CD101hi lung tissue–infiltrating eosinophils that are differentially regulated by type 2 cytokines

SL Noble, F Vacca, KL Hilligan… - … and Cell Biology, 2024 - Wiley Online Library
… Strikingly, we show that the two eosinophil subtypes have distinct anatomical localization
within … Lung-resident eosinophils represent a distinct regulatory eosinophil subset. J Clin Invest …

Eosinophil subtypes in adults with asthma and adults with chronic obstructive pulmonary disease

C Cabrera López, A Sánchez Santos… - American Journal of …, 2023 - atsjournals.org
… in metabolic regulation and … be different subtypes of eosinophils in patients with those
diseases. This hypothesis is also supported by the presence of two different types of eosinophils in …

Eosinophils as drivers of severe eosinophilic asthma: endotypes or plasticity?

G Van Hulst, F Bureau, CJ Desmet - International Journal of Molecular …, 2021 - mdpi.com
… Siglec-F + eosinophil subsets with distinct gene expression profiles were … Regulatory
and “inflammatory” eosinophil subsets were also detected in the murine models of eosinophilic

Single-Cell Analysis Uncovers Striking Cellular Heterogeneity of Lung-Infiltrating Regulatory T Cells during Eosinophilic versus Neutrophilic Allergic Airway …

S Iamsawat, R Yu, S Kim, N Dvorina, K Qiu… - The Journal of …, 2024 - journals.aai.org
… inflammation may give rise to phenotypically distinct lung-resident Tregs, underscoring a (to …
without separating lung-resident Treg subsets from circulating Treg subsets within the lung. …