Stress relief techniques: p38 MAPK determines the balance of cell cycle and apoptosis pathways

RH Whitaker, JG Cook - Biomolecules, 2021 - mdpi.com
activated protein kinases (MAPKs) are components of kinasesignaling pathways and
cell regulatory mechanisms, in this review we focus on the roles that the p38 stress pathway

p38 MAPK pathway in the heart: new insights in health and disease

R Romero-Becerra, AM Santamans… - International Journal of …, 2020 - mdpi.com
… shown to decrease oxidative stress and block the activation of p38 and JNK, thus reducing
apoptosis during ischemia–reperfusion [68]. Moreover, oxidative stress can directly regulate …

Understanding MAPK signaling pathways in apoptosis

J Yue, JM López - International journal of molecular sciences, 2020 - mdpi.com
… /threonine kinase, which was termed MAP kinase (MAPK) as … The stress-activated JNKs and
p38 MAPKs play key roles in … to both extracellular and intracellular stresses (reviewed in [12…

Involvement of p38 MAPK in synaptic function and dysfunction

C Falcicchia, F Tozzi, O Arancio, DM Watterson… - International journal of …, 2020 - mdpi.com
… Each isoform of the p38 MAPK enzyme is activated by dual … by either MAP kinase kinase 3
(MKK3) or MAP kinase kinase 6 … , the differential activation of stress related kinases, p38mapk, …

Is p38 MAPK associated to drugs of abuse-induced abnormal behaviors?

R El Rawas, IM Amaral, A Hofer - International Journal of Molecular …, 2020 - mdpi.com
… of the mitogen-activated protein kinases (MAPK) mediate a wide … of p38 MAPK in stress,
anxiety, and depression. We opine that p38 MAPK activation is more closely associated to stress-…

Functions of p38 MAP kinases in the central nervous system

PR Asih, E Prikas, K Stefanoska, ARP Tan… - Frontiers in molecular …, 2020 - frontiersin.org
… of p38 activation are cellular stressors such as oxidative stress, … Upstream stimuli activate a
MAP kinase kinase kinase (… MLK or TAO kinases, which in turn phosphorylate and activate a …

Diversity and versatility of p38 kinase signalling in health and disease

B Canovas, AR Nebreda - Nature reviews Molecular cell biology, 2021 - nature.com
… of the mitogen-activated protein kinase (MAPK) … of p38 kinase signalling compared with
stress and cytokines 66,67 . We discuss below examples of pathways involved in p38α activation

Impact of environmental toxicants on p38-and ERK-MAPK signaling pathways in the central nervous system

OM Ijomone, JD Iroegbu, M Aschner, J Bornhorst - Neurotoxicology, 2021 - Elsevier
… -activated protein kinases (MAPKs) signalling pathways, which include the extracellular
signal-regulated protein kinase (ERK) and the p38-MAPK, … and oxidative stress by disrupting the …

The p38 pathway: from biology to cancer therapy

A Martínez-Limón, M Joaquin, M Caballero… - International journal of …, 2020 - mdpi.com
… The p38 MAPK pathway is well known for its role in transducing stress signals from the …
Mitogen-activated protein kinase (MAPK) cascades are signaling components that show a high …

The p38 MAPK signaling activation in colorectal cancer upon therapeutic treatments

A Pranteda, V Piastra, L Stramucci… - International Journal of …, 2020 - mdpi.com
… exact role of the p38 MAPK pathway in response to currently … intricate scenario in which the
p38 MAPK node presents many … stress-activated p38 mitogen activated protein kinase (MAPK