Overexpression of bone morphogenetic protein receptor type 2 suppresses transforming growth factor β-induced profibrotic responses in lung fibroblasts
J Fukihara, S Maiolo, J Kovac, K Sakamoto… - Experimental Lung …, 2022 - Taylor & Francis
… Purpose of the study: Idiopathic pulmonary fibrosis (… bone morphogenetic proteins (BMPs)
are known to be antifibrotic and may counterbalance TGF-β signaling via BMP receptor type 2 (…
are known to be antifibrotic and may counterbalance TGF-β signaling via BMP receptor type 2 (…
A New Treatment Strategy for Pulmonary Fibrosis Targeting the Bone Morphogenetic Protein Pathway, and the Importance of Radiological Pattern for Selecting …
J Fukihara - 2022 - digital.library.adelaide.edu.au
… Idiopathic pulmonary fibrosis (IPF) is a progressive disease … Conversely, bone morphogenetic
protein (BMP)4 and 7 bind … observed in bone-marrow derived macrophages in IPF lungs (…
protein (BMP)4 and 7 bind … observed in bone-marrow derived macrophages in IPF lungs (…
Vascular–parenchymal cross-talk promotes lung fibrosis through BMPR2 signaling
T Yanagihara, K Tsubouchi, Q Zhou… - American Journal of …, 2023 - atsjournals.org
… Field: This study demonstrates that pulmonary fibrosis … idiopathic pulmonary fibrosis
undergoing transplantation and biological impacts on BMPR2 (bone morphogenic protein receptor 2…
undergoing transplantation and biological impacts on BMPR2 (bone morphogenic protein receptor 2…
Bone morphogenetic protein 4 inhibits pulmonary fibrosis by modulating cellular senescence and mitophagy in lung fibroblasts
R Guan, L Yuan, J Li, J Wang, Z Li, Z Cai… - European …, 2022 - Eur Respiratory Soc
… Bone morphogenetic protein (BMP)4 is downregulated in lungs and lung fibroblasts from
idiopathic pulmonary fibrosis (IPF) patients and bleomycin (BLM)-injured mice. a) …
idiopathic pulmonary fibrosis (IPF) patients and bleomycin (BLM)-injured mice. a) …
Macrophages in lung injury, repair, and fibrosis
P Cheng, S Li, H Chen - Cells, 2021 - mdpi.com
… the role of macrophage polarization in the pulmonary fibrotic … Idiopathic pulmonary fibrosis
(IPF) is a chronic and … in progressive pulmonary fibrosis, and depletion of M2 macrophages, …
(IPF) is a chronic and … in progressive pulmonary fibrosis, and depletion of M2 macrophages, …
[HTML][HTML] Novel strategy of combined interstitial macrophage depletion with intravenous targeted therapy to ameliorate pulmonary fibrosis
Z Li, Q Zhang, J Xiang, M Zhao, Y Meng, X Hu, T Li… - Materials Today Bio, 2023 - Elsevier
… it inhibited pulmonary macrophages, reduced macrophage depletion in non-target organs,
improved pulmonary … Idiopathic pulmonary fibrosis (IPF) is an irreversible and fatal interstitial …
improved pulmonary … Idiopathic pulmonary fibrosis (IPF) is an irreversible and fatal interstitial …
Adverse effects of BMPR2 suppression in macrophages in animal models of pulmonary hypertension
J West, X Chen, L Yan, S Gladson, J Loyd… - Pulmonary …, 2020 - journals.sagepub.com
… Macrophage bone morphogenic protein receptor 2 depletion in idiopathic pulmonary fibrosis
and Group III pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol 2016; 311: L238…
and Group III pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol 2016; 311: L238…
Alveolar epithelial type II cells as drivers of lung fibrosis in idiopathic pulmonary fibrosis
… the AT2 cell and evidence for both AT2 depletion and dysfunction as contributors to IPF. …
protein-1 (MCP-1, also known as CC motif ligand 2 (CCL2)) that in turn promoted macrophage …
protein-1 (MCP-1, also known as CC motif ligand 2 (CCL2)) that in turn promoted macrophage …
Alveolar epithelial type 2 cell dysfunction in idiopathic pulmonary fibrosis
W Zhu, C Tan, J Zhang - Lung, 2022 - Springer
… that specific depletion of AT2 cells induces pulmonary fibrosis in … protein C (SPC) promoter
and the diphtheria toxin receptor gene (… of macrophages, and promote pulmonary fibrosis [29]. …
and the diphtheria toxin receptor gene (… of macrophages, and promote pulmonary fibrosis [29]. …
Macrophage phenotypes and repair function in lung fibrosis
D Schlösser - 2024 - oparu.uni-ulm.de
… can functionally replenish the niche after depletion of cardiac macrophages or in response
… al. reported that also alveolar macrophages derived from Idiopathic pulmonary fibrosis (IPF) …
… al. reported that also alveolar macrophages derived from Idiopathic pulmonary fibrosis (IPF) …