Staying true to yourself: mechanisms of DNA methylation maintenance in mammals

N Petryk, S Bultmann, T Bartke… - Nucleic acids …, 2021 - academic.oup.com
… of this epigenetic modification takes place during and after DNA replication, and occurs …
of DNA methylation maintenance in mammals. We also discuss how it could be regulated in …

Role of mammalian DNA methyltransferases in development

Z Chen, Y Zhang - Annual review of biochemistry, 2020 - annualreviews.org
… of the regulation of DNA methylation dynamics in mammalian germ lines and … ), DNA
methylation is vital for maintaining genome stability in eukaryotes. In mammals, DNA methylation

DNA methylation and regulation of gene expression: Guardian of our health

GA Dhar, S Saha, P Mitra, R Nag Chaudhuri - The Nucleus, 2021 - Springer
mammals, imprinted genes retain their tags, ie, these genes begin their functions with earlier
epigenetic tags. Interestingly in mammals… the maintenance of DNA methylation patterns in …

DREAM complex suppresses DNA methylation maintenance genes and precludes DNA hypermethylation

YQ Ning, N Liu, KK Lan, YN Su, L Li, S Chen, XJ He - Nature Plants, 2020 - nature.com
… Given that the DREAM complexes are conserved from plants to animals, the preclusion
of DNA hypermethylation by DREAM complexes may represent a conserved mechanism in …

DNA methylation networks underlying mammalian traits

A Haghani, CZ Li, TR Robeck, J Zhang, AT Lu… - Science, 2023 - science.org
Using DNA methylation profiles (n = 15,456) from 348 mammalian species, we constructed
phyloepigenetic trees that bear marked similarities to traditional phylogenetic ones. Using …

Maintenance DNA methylation is essential for regulatory T cell development and stability of suppressive function

KA Helmin, L Morales-Nebreda… - The Journal of …, 2020 - Am Soc Clin Investig
… Indeed, the ex-Foxp3 cells that we observed in adult control animals did not display an
inflammatory gene expression profile, but did exhibit increased super-enhancer …

Universal DNA methylation age across mammalian tissues

AT Lu, Z Fei, A Haghani, TR Robeck, JA Zoller, CZ Li… - Nature aging, 2023 - nature.com
… damage, can be accurately estimated using DNA methylation profiles, the foundation of pan-…
pan-mammalian clocks, using 11,754 methylation arrays from our Mammalian Methylation

Universal DNA methylation age across mammalian tissues

AT Lu, Z Fei, A Haghani, TR Robeck, JA Zoller, CZ Li… - BioRxiv, 2021 - biorxiv.org
mammalian clocks that measure age in all mammalian species. To address this, we generated
data using 11,754 methylation … of DNA, from 59 tissue-types derived from 185 mammalian

DNA methylation: a historical perspective

AL Mattei, N Bailly, A Meissner - Trends in Genetics, 2022 - cell.com
… key factors that establish, maintain, and remove DNA methylation and have access to a …
DNA methylation from its beginning to present day, with an emphasis on findings in mammalian

DNA methylation changes during preimplantation development reveal inter-species differences and reprogramming events at imprinted genes

E Ivanova, S Canovas, S Garcia-Martínez, R Romar… - Clinical …, 2020 - Springer
… It also provides new insights into establishment and maintenance of DNA methylation
imprints. Data are of utmost importance as a reference for species similarity and differences in …