CD8+ T cell metabolism in infection and cancer

M Reina-Campos, NE Scharping… - Nature Reviews …, 2021 - nature.com
… killing of infected cells, while long-lived memory CD8 + T cellusing this in vitro system
suggested that memory CD8 + T … to couple oxidative phosphorylation with the generation of ATP …

[HTML][HTML] Signature of long-lived memory CD8+ T cells in acute SARS-CoV-2 infection

S Adamo, J Michler, Y Zurbuchen, C Cervia… - Nature, 2022 - nature.com
… Here, using spectral flow cytometry combined with cellular … -Dex + cells longitudinally,
at both the population level and … for memory generation 34 . As we sampled SARS-CoV-2-specific …

[HTML][HTML] Exposure to SARS-CoV-2 generates T-cell memory in the absence of a detectable viral infection

Z Wang, X Yang, J Zhong, Y Zhou, Z Tang… - Nature …, 2021 - nature.com
… of IFNγ + T cells ± SEM; Percentage shown on top of the … may have led to the generation
of T cell immunity even in the … contacts and 30 healthy donors by using an overnight “ex vivo” …

The architectural design of CD8+ T cell responses in acute and chronic infection: Parallel structures with divergent fates

HK Chung, B McDonald, SM Kaech - Journal of Experimental Medicine, 2021 - rupress.org
… goal of generating large numbers of effector T cells to help … Comparative analyses of the
effector and memory CD8 + T cell … As the determination of cell subsets or states using single-cell

[HTML][HTML] Stochastic episodes of latent cytomegalovirus transcription drive CD8 T-cell memory inflation” and avoid immune evasion

M Griessl, A Renzaho, K Freitag, CK Seckert… - Frontiers in …, 2021 - frontiersin.org
… the memory CD8 + T-cell response to natural infections with … of MI by generating the
epitope-specific cells that can later be re-… of peptide-specific CD8 + T cells was performed using

Metabolic regulation by PD-1 signaling promotes long-lived quiescent CD8 T cell memory in mice

V Kalia, Y Yuzefpolskiy, A Vegaraju, H Xiao… - Science translational …, 2021 - science.org
memory CD8 T cells at day 22 after infection (when WT … 1 is critical for generating optimal
numbers of memory CD8 T cells. By … to manipulate the durability of CD8 T cell immune memory. …

Tissue-resident memory CD8+ T cells shape local and systemic secondary T cell responses

FM Behr, L Parga-Vidal, NAM Kragten… - Nature …, 2020 - nature.com
… specifically visualize and manipulate T RM cells. Therefore, … Hobit-expressing OT-I T cells
after primary infection (Fig. 2a). … Mapping and generation of count tables were done using the …

[PDF][PDF] The PD-1 pathway regulates development and function of memory CD8+ T cells following respiratory viral infection

KE Pauken, J Godec, PM Odorizzi, KE Brown, KB Yates… - Cell reports, 2020 - cell.com
… of PD-1 blockade determines impact on memory generation … effector and memory CD8+
T cells following acute infections. … differentiation during influenza virus infection using mice …

[HTML][HTML] The precursors of CD8+ tissue resident memory T cells: from lymphoid organs to infected tissues

L Kok, D Masopust, TN Schumacher - Nature Reviews Immunology, 2022 - nature.com
… You are using a browser version with limited support for CSS. To … T RM cell lineage, resulting
in the generation of a pool of TT cells, at the level of both naive and early effector T cells, to …

[HTML][HTML] Metabolic reprogramming in CD8+ T cells during acute viral infections

SS Gupta, J Wang, M Chen - Frontiers in Immunology, 2020 - frontiersin.org
… types in CD8 + T cells; as determined using several cellular … that ultimately results in the
generation of 2.5 ATP per NADH … effector CD8 + T cells differentiate into memory CD8 + T cells