Developmental plasticity allows outside-in immune responses by resident memory T cells

R Fonseca, LK Beura, CF Quarnstrom… - Nature …, 2020 - nature.com
… , and memory CD8 + T cell subsets expressing identical T cell … Library preparation and
sequencing for the generation of … and CD8 + T cells were purified using a CD8 + T cell Negative …

[HTML][HTML] B cells promote CD8 T cell primary and memory responses to subunit vaccines

J Klarquist, EW Cross, SB Thompson, B Willett… - Cell reports, 2021 - cell.com
Primary and memory CD8 T responses to vaccines are … certain infections in B-cell-deficient
mice. Here, we find that B … A specific role for B cells in the generation of CD8 T cell memory by …

Replicative history marks transcriptional and functional disparity in the CD8+ T cell memory pool

K Bresser, L Kok, AC Swain, LA King, L Jacobs… - Nature …, 2022 - nature.com
… a–c, Kinetics of DR + OT-I T cells (a) and the percentage of … were superior in generating
offspring upon renewed infectionUsing the DivisionRecorder, we demonstrate that, as a whole…

[HTML][HTML] Targeting memory T cell metabolism to improve immunity

M Corrado, EL Pearce - The Journal of clinical investigation, 2022 - Am Soc Clin Investig
… how Tm cells are generated upon acute infection, how such … priming resting T cells and
generating long-lasting Tm cells was … that CAR T cell efficiency can be manipulated by metabolic …

Circulating memory CD8+ T cells are limited in forming CD103+ tissue‐resident memory T cells at mucosal sites after reinfection

FM Behr, A Beumer‐Chuwonpad… - European journal of …, 2021 - Wiley Online Library
… by effector and memory CD8 + T cells, mice were infected with … Using adoptive transfer and
rechallenge approaches, we … the generation of secondary circulating memory CD8 + T cells, …

Epigenetic scarring of exhausted T cells hinders memory differentiation upon eliminating chronic antigenic stimulation

MS Abdel-Hakeem, S Manne, JC Beltra… - Nature …, 2021 - nature.com
Memory CD8 T cells (T MEM ) persist long-term, can self-… Here, we addressed these
questions using the mouse model … of generating appropriately differentiated secondary T EFF . …

Inhibitory signaling sustains a distinct early memory CD8+ T cell precursor that is resistant to DNA damage

JB Johnnidis, Y Muroyama, SF Ngiow, Z Chen… - Science …, 2021 - science.org
Generation of memory T cells is an essential part of protective immunity against pathogens
after initial infection … improve CD8 + T cell memory after vaccination through manipulating the …

Influenza, but not SARS‐CoV‐2, infection induces a rapid interferon response that wanes with age and diminished tissue‐resident memory CD8+ T cells

THO Nguyen, JL McAuley, Y Kim… - Clinical & …, 2021 - Wiley Online Library
… response following infection with influenza virus and severe acute … A, and the percentage
of different immune cells generating … -specific memory CD8 + T cells in lung of donors using a …

Control of memory CD8+ T cell longevity and effector functions by IL-15

JC Nolz, MJ Richer - Molecular immunology, 2020 - Elsevier
… the memory CD8 + T cell response against re-infections. … In addition, the generation of soluble
IL-15/IL-15Rα complexes have … at manipulating the function of memory CD8 + T cells will …

[HTML][HTML] Metabolic Reprogramming in CD8+ T Cells During Acute Viral Infections

SS Gupta, J Wang, M Chen - Frontiers in Immunology, 2020 - frontiersin.org
… types in CD8 + T cells; as determined using several cellular … that ultimately results in the
generation of 2.5 ATP per NADH … effector CD8 + T cells differentiate into memory CD8 + T cells