Epigenetic scars of CD8+ T cell exhaustion persist after cure of chronic infection in humans
… the regulation of exhausted T cells at the epigenetic level. … and restrains the generation of
protective memory T cell responses. … CD8 + T cells were enriched using a MACS CD8 negative …
protective memory T cell responses. … CD8 + T cells were enriched using a MACS CD8 negative …
[HTML][HTML] SARS-CoV-2 viral RNA shedding for more than 87 days in an individual with an impaired CD8+ T cell response
JS Turner, BK Patterson, AH Ellebedy… - Frontiers in …, 2021 - frontiersin.org
… The reaction was stopped after 5 min using 100 µL 1M … as measured by percentage of CD8+
T cells in live CD45+ … the importance of CD8+ T cells in the clearance of viral infections (14, …
T cells in live CD45+ … the importance of CD8+ T cells in the clearance of viral infections (14, …
Interferon regulatory factor 4 controls effector functions of CD8+ memory T cells
A Harberts, C Schmidt, J Schmid… - Proceedings of the …, 2021 - National Acad Sciences
… The function of IRF4 in memory CD8 + T cells yet needs to … Irf4-deficient genotype by CD8
+ T cells after infection did not … late phase of the acute LCMV response using Cre expression …
+ T cells after infection did not … late phase of the acute LCMV response using Cre expression …
Zbtb20 restrains CD8 T cell immunometabolism and restricts memory differentiation and antitumor immunity
… ratio is low, is required for memory CD8 T cell generation (11, 12). … and memory CD8 T cells,
we differentiated OT-I cells in vitro … Using the same OT-I transfer and LM-actA–OVA infection …
we differentiated OT-I cells in vitro … Using the same OT-I transfer and LM-actA–OVA infection …
Allelic variation in class I HLA determines CD8+ T cell repertoire shape and cross-reactive memory responses to SARS-CoV-2
…, A Moarefi, M Noble, T Malia… - Science …, 2021 - science.org
… to CD8 + T cells is required for viral elimination and generation of long… We defined the
phenotypic features of clusters using gene … memory CD8 + T cells. The extent to which pre-existing …
phenotypic features of clusters using gene … memory CD8 + T cells. The extent to which pre-existing …
Helminth Infection–Induced Increase in Virtual Memory CD8 T Cells Is Transient, Driven by IL-15, and Absent in Aged Mice
… Using these two characteristically distinct helminth infection … infection and the rates of
proliferation and conversion to a T VM … T VM cells and not by de novo generation from T N cells. …
proliferation and conversion to a T VM … T VM cells and not by de novo generation from T N cells. …
SARS-CoV-2-specific T cell memory is sustained in COVID-19 convalescent patients for 10 months with successful development of stem cell-like memory T cells
JH Jung, MS Rha, M Sa, HK Choi, JH Jeon… - Nature …, 2021 - nature.com
… -2-specific T cell responses up to 8 months after infection using … Using diverse T cell assays,
we show that SARS-CoV-2-… period and the successful generation of T SCM cells. We also …
we show that SARS-CoV-2-… period and the successful generation of T SCM cells. We also …
Cutting edge: Batf3 expression by CD8 T cells critically regulates the development of memory populations
Z Qiu, C Khairallah, G Romanov… - The Journal of …, 2020 - journals.aai.org
… were enriched from the mesenteric lymph nodes (MLN) using … by CD8 T cells does not
regulate the generation of intestinal … memory CD8 T cell development in part by promoting CD8 T …
regulate the generation of intestinal … memory CD8 T cell development in part by promoting CD8 T …
Environmental cues regulate epigenetic reprogramming of airway-resident memory CD8+ T cells
SL Hayward, CD Scharer, EK Cartwright… - Nature …, 2020 - nature.com
… a second analysis using FluNP + CD8 + T cells sorted from … after x31 infection, which
included FluNP + IV + CD8 + T EM … of infection and housed under specific animal biosafety level …
included FluNP + IV + CD8 + T EM … of infection and housed under specific animal biosafety level …
[HTML][HTML] Tissue-resident memory T cells in the lungs protect against acute respiratory syncytial virus infection
MA Luangrath, ME Schmidt, SM Hartwig… - …, 2021 - journals.aai.org
… RSV-specific memory CD8 T cells via a dendritic cell–Listeria … timepoint using a murine
model. We demonstrated that both … Therefore, acute RSV infection leads to the generation of RSV…
model. We demonstrated that both … Therefore, acute RSV infection leads to the generation of RSV…