[HTML][HTML] Signature of long-lived memory CD8+ T cells in acute SARS-CoV-2 infection

S Adamo, J Michler, Y Zurbuchen, C Cervia… - Nature, 2022 - nature.com
… Here, using spectral flow cytometry combined with cellular … -Dex + cells longitudinally,
at both the population level and … for memory generation 34 . As we sampled SARS-CoV-2-specific …

[HTML][HTML] Sepsis leads to lasting changes in phenotype and function of memory CD8 T cells

IJ Jensen, X Li, PW McGonagill, Q Shan, MG Fosdick… - Elife, 2021 - elifesciences.org
… Here, using samples from septic patients and well described … LCMV-infection model to
establish memory CD8 T cells followed … This system of memory generation and sepsis induction …

Peripherally induced brain tissue–resident memory CD8+ T cells mediate protection against CNS infection

SL Urban, IJ Jensen, Q Shan, LL Pewe, HH Xue… - Nature …, 2020 - nature.com
… , we compared CNS T RM cell generation in mice infected in with … The percentage of IV –
antigen-specific cells in the upper … TCR-tg T cell populations were gated using FlowJo software …

CD8+ T cell metabolism in infection and cancer

M Reina-Campos, NE Scharping… - Nature Reviews …, 2021 - nature.com
… killing of infected cells, while long-lived memory CD8 + T cellusing this in vitro system
suggested that memory CD8 + T … to couple oxidative phosphorylation with the generation of ATP …

Tissue-resident memory CD8+ T cells shape local and systemic secondary T cell responses

FM Behr, L Parga-Vidal, NAM Kragten… - Nature …, 2020 - nature.com
… specifically visualize and manipulate T RM cells. Therefore, … Hobit-expressing OT-I T cells
after primary infection (Fig. 2a). … Mapping and generation of count tables were done using the …

The architectural design of CD8+ T cell responses in acute and chronic infection: Parallel structures with divergent fates

HK Chung, B McDonald, SM Kaech - Journal of Experimental Medicine, 2021 - rupress.org
… goal of generating large numbers of effector T cells to help … Comparative analyses of the
effector and memory CD8 + T cell … As the determination of cell subsets or states using single-cell

[HTML][HTML] Exposure to SARS-CoV-2 generates T-cell memory in the absence of a detectable viral infection

Z Wang, X Yang, J Zhong, Y Zhou, Z Tang… - Nature …, 2021 - nature.com
… of IFNγ + T cells ± SEM; Percentage shown on top of the … may have led to the generation
of T cell immunity even in the … contacts and 30 healthy donors by using an overnight “ex vivo” …

[HTML][HTML] Diverse CD8 T cell responses to viral infection revealed by the collaborative cross

MD Martin, R Sompallae, CS Winborn, JT Harty… - Cell reports, 2020 - cell.com
… factors influencing memory CD8 T cell generation and characteristics of … CD8 T cells dictate
the level of host protection against re-… memory CD8 T cells with time after primary infection. …

Prior vaccination promotes early activation of memory T cells and enhances immune responses during SARS-CoV-2 breakthrough infection

MM Painter, TS Johnston, KA Lundgreen… - Nature …, 2023 - nature.com
… , we assessed CD8 T cell responses using multiplexed human … without preventing the
generation of de novo responses to … of pre-infection spike-specific memory CD8 T cells toward the …

Differentiation of exhausted CD8+ T cells after termination of chronic antigen stimulation stops short of achieving functional T cell memory

…, L Massenet-Regad, T Eisenhaure… - Nature …, 2021 - nature.com
… of HCV-specific CD8 + T cells using HLA class I multimers … in each patient using next-generation
viral sequencing (Fig. … versus memory CD8 + T cell (C7)’ enriched in pre-DAA T EX cells