The mar, sox, and rob Systems

LM Chubiz - EcoSal Plus, 2023 - Am Soc Microbiol
… class I MarA binding orientation and class II MarA positioning to produce a scenario
where MarA interferes with RNP promoter interactions resulting in transcriptional repression. …

Mapping direct and indirect MarA/SoxS/Rob/RamA regulons in Salmonella Typhimurium reveals repression of csgD and biofilm formation

AD Middlemiss, JRJ Haycocks, AM Stringer… - …, 2023 - microbiologyresearch.org
… In our conditions, all promoters targeted by MarA, SoxS, Rob or RamA had sequence … coli,
we identified a mechanism for MarA-mediated repression of biofilm production [34]. Briefly, …

Multiple antibiotic resistance in gram-negative bacteria: controlling cell envelope barrier function

AE Trigg - 2023 - etheses.bham.ac.uk
… SoxS and Rob bind the marbox in the promoter regions of lpxC, lpxL, waaY and pbpG120
4.6. In vivo regulation of lpxL, waaY and pbpG by MarA and SoxS .................................... 120 …

Elucidation of Key Interactions between VirF and the virB Promoter in Shigella flexneri Using E. coli MarA- and GadX-Based Homology Models and In Vitro Analysis …

NJ Ragazzone, GT Dow, GA Garcia - Journal of Bacteriology, 2022 - Am Soc Microbiol
… to other DNA promoter sequences in addition to the promoters used within this study. MarA
binds to specific promoter sequences termed the marbox, which control transcription of >15 …

Elucidating Protein-DNA Recognition by the Bacterial Transcription Factors MarA and VirF by Homology Modeling and DNA-Binding Studies of Wild-type and Mutant …

N Ragazzone - 2022 - deepblue.lib.umich.edu
… weaker binding to the virB promoter relative to WT. … Rob structure, using cryogenic electron
microscopy (cryo-EM) to obtain a density map and structural model of Rob in a transcription

An Intertwined Network of Regulation Controls Membrane Permeability Including Drug Influx and Efflux in Enterobacteriaceae

A Ferrand, J Vergalli, JM Pagès, A Davin-Regli - Microorganisms, 2020 - mdpi.com
… specific repressor naturally bounds on marO promoter and … -, SoxS-, and Rob-mediated
activation of transcription [72]. CsrA is … The first study of a post-transcriptional repression of porin …

RND Efflux Pump Induction: A Crucial Network Unveiling Adaptive Antibiotic Resistance Mechanisms of Gram-Negative Bacteria

M Novelli, JM Bolla - Antibiotics, 2024 - mdpi.com
… MexR attachment to the intergenic promoter region, leading to … interaction between the
transcriptional repressor SmeT and its … transcription of the Rob regulon. The low-activity form of …

The multidrug efflux pump regulator AcrR directly represses motility in Escherichia coli

J Maldonado, B Czarnecka, DE Harmon, C Ruiz - Msphere, 2023 - Am Soc Microbiol
transcriptional repressor AcrR is known to directly repress … enterica, the transcriptional
regulators MarA, SoxS, Rob, and … our analysis on hits with promoter regions that contained at least …

Resistance to DNA Interstrand Crosslinks in Escherichia coli Arises through Prevention Rather Than Repair

TK Worley - 2023 - search.proquest.com
… stress-inducible promoters by Escherichia coli Rob protein. J … Many chromosomal genes
modulate MarA-mediated multidrug … into the mechanisms of transcriptional repression and multi-…

Fitness costs in antibiotic resistance and metabolic engineering

T Wang - 2020 - search.proquest.com
… Salicylate increases fitness cost associated with MarA-mediated … In this work, we
focused on the cost of MarA-mediated … This work suggests that the fitness cost of MarA-mediated