… maternal intake of folic acid reduces the risk of CHD [Citation15–17], multiple studies have
focused on identifying genetic and metabolic risk factors of … that hyperhomocysteinemia during …

… So mutation of CBS gene impairs the stability of enzyme and decreases the catalytic activity
[39], leading to accumulation of hcy in the body and the hyperhomocysteinemia (HHcy). In …

… levels of Hcy is a known risk factor for human diseases. Kilmer reviewed the chemical …
population-based studies that maternal hyperhomocysteinemia was significantly associated with …

… Hyperhomocysteinemia (HHcy) can be caused by dietary deficiencies in folic acid, vitamin
B6, and/or vitamin B12; … Congenital heart disease in maternal phenylketonuria: report from the …

… congenital heart disease (CHD). This study examined the role of MTHFD1 gene and maternal
smoking on infant CHD risk… likely shared some etiologic and specifically genetic risk factors…

… to examine maternal risk factors for CHD, two groups of mothers were compared; mothers of
… Statistically significant differences in the incidence of congenital heart defects with respect to …

… factors, our results suggested that the maternal MTHFR rs1801133 polymorphism might be
a risk factor of their … factor of offspring CHDs due to the hyperhomocysteinemia by abnormal …

… and role of folic acid in ameliorating hyperhomocysteinemia [1]. Since folic acid as a crucial
… up hyperhomocysteinemia [6]. A positive correlation exists between the levels of maternal …

… mother’s hyperhomocysteinemia are associated with the risk of having a child with congenital
heart disease… homocysteine itself is a risk factor for congenital heart disease or changes in …

… genetic causes of severe hyperhomocysteinemia, associated with … subjects and concluded
that mothers with NTD offspring had … biomarkers in children with congenital heart diseases. …