… observed that mature cultures of primary cortical neurons resist … Mature neurons restrict the
expression of Apaf-1 through … redundant. To take the advantage of the unique regulation of …

… to human brain cells, including mature neurons that upregulate … , metabolic stress and
loosening of apoptotic brakes. … ‘cancer of neurons’, and it might thus be more useful to prevent age-…

… of pharmacological inhibition to prevent both process from occurring … of anti-apoptotic proteins,
removing the brake that prevents cells … Unfortunately, adult neuron populations still die in …

… regulation enforcing restriction of neuronal apoptosis is largely unknown. … that mature
neurons can be restrained from activating apoptosis by engaging multiple redundant anti-apoptotic …

… the number of neurons in the mature nervous system is … deletion alone is insufficient to prevent
apoptosis entirely in the Mcl-… Mcl-1 are dynamic, changing through development and with …

… Apoptosis is an effective and efficient mechanism of cell death involving robust activation of
caspases. More mature neurons … attributed to their restriction of apoptotic pathways, though …

… characterized restricted cell death in neurons (84… neurons quiescently infected with
Stayput-GFP using a combination of stimuli. Neonatal sympathetic neurons or adult sensory neurons …

… In vitro, the ZNS treatment inhibited both the apoptosis of the neuronal cells and apoptosis-related
… Mature neurons dynamically restrict apoptosis via redundant premitochondrial brakes. …

… of Bak in mature neurons represents one of the pre-mitochondrial apoptotic brakes. Most …
Whether that constitutes also a developmentally acquired mechanism to restrain apoptotic …

… the ganglia or prevent the fragmented neuron phenotype at 48 … Adult neurons are resistant
to apoptosis, however some … T cells play a limited or redundant role in regulating the direct …