Molecular and biomechanical adaptations to mechanical stretch in cultured myotubes

D Ren, J Song, R Liu, X Zeng, X Yan, Q Zhang… - Frontiers in …, 2021 - frontiersin.org
… the mutual effects of anabolic and catabolic signaling, rather than … regulate AChE expression
in the neuromuscular junctions that undergo intense mechanical distortions during exercise

Osteocyte-mediated translation of mechanical stimuli to cellular signaling and its role in bone and non-bone-related clinical complications

Y Yan, L Wang, L Ge, JL Pathak - Current osteoporosis reports, 2020 - Springer
Mechanical loading and unloading modulate the osteocytic … a wide range of signaling
molecules regulating the activity of … mechanical stimuli to bone anabolic cellular signaling, and …

Bone's response to mechanical loading in aging and osteoporosis: molecular mechanisms

V Carina, E Della Bella, V Costa, D Bellavia… - Calcified tissue …, 2020 - Springer
… and convert mechanical stress into biological signals (bone … by regulating different processes
[60] and its activity is … , by altering the anabolic response of bone to mechanical stress [71]. …

Cellular and molecular pathways controlling muscle size in response to exercise

M Attwaters, SM Hughes - The FEBS journal, 2022 - Wiley Online Library
… The general bodily hormonal status may modulate the gain … which signals regulate which
aspect and how these signals … concert with mechanical signals to drive anabolism in response …

Emerging strategies targeting catabolic muscle stress relief

M Scalabrin, V Adams, S Labeit, TS Bowen - … Journal of Molecular …, 2020 - mdpi.com
… the molecular pathways involved in regulating skeletal … /nutrient, mechanical load, and
neural activity, which helps to … in anabolic signaling pathways being primarily modulated as a …

[HTML][HTML] … the brakes on autophagy: The role of heparan sulfate modified proteins in the balance of anabolic and catabolic pathways and intracellular quality control

N Schultheis, M Jiang, SB Selleck - Matrix Biology, 2021 - Elsevier
activity and are therefore positioned within signaling networks that inhibit, or negatively
regulate … provide an evolutionarily conserved inhibitory modulation of autophagy that can have …

Molecular networks underlying cannabinoid signaling in skeletal muscle plasticity

S Dalle, M Schouten, G Meeus… - Journal of Cellular …, 2022 - Wiley Online Library
… in (i) how cannabinoid signaling is regulated via receptor-… networks that drive the muscle
toward a more pro-anabolic, … ) also modulated the training responses to resistance exercise, be …

Metabo-reciprocity in cell mechanics: feeling the demands/feeding the demand

S Torrino, T Bertero - Trends in Cell Biology, 2022 - cell.com
… to face their rapidly growing anabolic demands. Cells can use … regulation between cell
metabolism and cell mechanics (… , and the expression, activity, and localization of metabolic …

Analysis of mechanotransduction dynamics during combined mechanical stimulation and modulation of the extracellular-regulated kinase cascade uncovers hidden …

G Ascolani, TM Skerry, D Lacroix… - Interface …, 2021 - royalsocietypublishing.org
… orchestrate the balance between the catabolic and anabolic process via communication with
mechanical signals can impose a nudge effect on ERK signalling towards anabolic activity

Sestrin prevents atrophy of disused and aging muscles by integrating anabolic and catabolic signals

J Segalés, E Perdiguero, AL Serrano… - Nature …, 2020 - nature.com
… In this study, we have made the surprising observation that not all catabolic activities are …
identified mTORC1-signaling regulation as another hallmark of sestrin modulation in muscle (…