Role of physical exercise and nutraceuticals in modulating molecular pathways of osteoarthritis

A de Sire, N Marotta, C Marinaro, C Curci… - … Journal of Molecular …, 2021 - mdpi.com
… This imbalance between anabolic and catabolic processes … of proteins, influencing signal
transduction, gene regulation, and cell … to mechanical stimulation activate the NF-κB signaling

Insights into the mechanical microenvironment within the cartilaginous endplate: An emerging role in maintaining disc homeostasis and normal function

P Xiang, ZP Luo, YJ Ch - Heliyon, 2024 - cell.com
… of the mechanical microenvironment on the cellular activities of … Tensile stress plays a crucial
role in regulating cell … loading can induce catabolism or counteract anabolism. Our study …

Mechanical loading rescues mechanoresponsiveness in a human osteoarthritis explant model despite Wnt activation

R Castro-Vinuelas, N Viudes-Sarrion… - Osteoarthritis and …, 2024 - Elsevier
regulation of the mRNA expression levels of different cartilage anabolic and catabolic
involves ECM adaptation to mechanical cues, 6 loading-induced MMPs activity may be required to …

[HTML][HTML] Modulating macrophage activities to promote endogenous bone regeneration: Biological mechanisms and engineering approaches

Y Niu, Z Wang, Y Shi, L Dong, C Wang - Bioactive materials, 2021 - Elsevier
… to mechanical stress and PTH stimulation, IL-11 potentiates Wnt signalling to induce osteogenesis
and to suppress adipogenesis; IL-11 can be down-regulated … early anabolism process …

[HTML][HTML] The potential role of exercise training and mechanical loading on bone-associated skeletal nerves

S Negri, TJ Samuel, S Lee - Journal of Bone Metabolism, 2021 - ncbi.nlm.nih.gov
exercise on skeletal nerve density and bone anabolic activity … evidence for the neural control
of bone metabolism and the … , exercise is known to increase the mechanical signals on the …

Mechanistic insight into the roles of integrins in osteoarthritis

H Jin, S Jiang, R Wang, Y Zhang, J Dong… - Frontiers in Cell and …, 2021 - frontiersin.org
… be driven by the imbalance between anabolic and catabolic activities of chondrocytes, which
are … Excessive mechanical signals can regulate key molecules in MAPK signal cascades to …

Piezo1-driven mechanotransduction as a key regulator of cartilage degradation in early osteoarthritis

X Yan, S Fu, Y Xie, C Zhang, X Wu - Biomolecules and Biomedicine, 2024 - bjbms.org
modulation of the PI3K signaling and matrix regulation … in cartilage, regulate both anabolic
and catabolic processes, … in regulating mechanical properties and catabolic activities in …

Protein turnover in skeletal muscle: looking at molecular regulation towards an active lifestyle

RP Ferreira, JA Duarte - International journal of sports …, 2023 - thieme-connect.com
… central mechanism that regulates catabolic signals from mechanical and metabolic stimulation
[… Akt is determinant in the control of both anabolic and catabolic signals. Its activity may be …

Cancer cachexia: molecular mechanisms and treatment strategies

T Setiawan, IN Sari, YT Wijaya, NM Julianto… - Journal of Hematology & …, 2023 - Springer
… pathology characterized by increased catabolic activity that leads to … the complex molecular
networks that regulate muscle mass … on homeostasis of the anabolic and catabolic pathways. …

[HTML][HTML] Osteoarthritis year in review 2022: biology

S Han - Osteoarthritis and cartilage, 2022 - Elsevier
… ) 4-mediated calcium signaling, (2) mechanical load–F-box and … synovial macrophages
promote catabolic activity of articular … between these catabolic and anabolic signaling govern the …