… The biochemical regulation of TET protein-mediated 5mC oxidation is not completely
understood. When the enzymatic reaction proceeds beyond 5hmC, and 5fC or 5caC are formed, …

… oxidizing 5-methylcytosine (m 5 C) to 5-hydroxymethylcytosine (hm 5 C) and further oxidized
… have demonstrated that m 5 C and TET protein-mediated oxidation are also important in the …

… make up a new class of enzymes that successively oxidizes 5-methylcytosine (5mC) to 5-…
others have shown that Tet protein mediated DNA methylation oxidation regulates gene …

… TET proteins gradually convert 5-methylcytosine into 5-hydroxymethylcytosine, 5-formylcytosine, …
suggest that TET proteins could also be involved in the oxidation of 5-methylcytosine in …

… Active demethylation is mediated by Ten-eleven Translocation (TET) dioxygenases. TET
enzymes oxidize 5-methylcytosine (m 5 C) to produce 5-hydroxymethylcytosine (hm 5 C), 5-…

… (TET) family as α-ketoglutarate- and Fe 2+ -dependent dioxygenase catalyzing the iterative
oxidation of 5-methylcytosine (… TET protein-mediated dynamic regulation of DNA methylation …

… Global hypomethylation is defined as a decrease in 5-methylcytosine content … TET mediated
oxidation of methylated cytosine form to successive unmodified cytosines by the enzyme TET…

… 5-methylcytosine (5-mC) and its oxidative derivative, … via TET protein mediated
hydroxymethylation of the methylated promoter regions in the oncogenes, thereby TET functioning as …

… that TET had catalytic activity in oxidizing 5-methylcytosine (… Ito et al. also found that TET
could further oxidize 5hmC to 5-… into adipocytes, TET protein-mediated DNA demethylation …

… TET) proteins catalyze the conversion of 5-methylcytosine (5mC) to 5hmC/5fC/5caC, which
could function … The dysregulation of TET family genes and aberrant 5mC oxidation have been …