Protein interactions at oxidized 5-methylcytosine bases
… The biochemical regulation of TET protein-mediated 5mC oxidation is not completely
understood. When the enzymatic reaction proceeds beyond 5hmC, and 5fC or 5caC are formed, …
understood. When the enzymatic reaction proceeds beyond 5hmC, and 5fC or 5caC are formed, …
Regulation of RNA Methylation by TET Enzymes
KM Banks, T Evans - Epitranscriptomics, 2021 - Springer
… oxidizing 5-methylcytosine (m 5 C) to 5-hydroxymethylcytosine (hm 5 C) and further oxidized
… have demonstrated that m 5 C and TET protein-mediated oxidation are also important in the …
… have demonstrated that m 5 C and TET protein-mediated oxidation are also important in the …
Deciphering the Role of TET2-mediated DNA Methylcytosine Oxidation in Cancer Immunotherapy
M Lee - 2020 - oaktrust.library.tamu.edu
… make up a new class of enzymes that successively oxidizes 5-methylcytosine (5mC) to 5-…
others have shown that Tet protein mediated DNA methylation oxidation regulates gene …
others have shown that Tet protein mediated DNA methylation oxidation regulates gene …
[HTML][HTML] TET protein inhibitors: Potential and limitations
R Kaplánek, Z Kejík, J Hajduch, K Veselá… - Biomedicine & …, 2023 - Elsevier
… TET proteins gradually convert 5-methylcytosine into 5-hydroxymethylcytosine, 5-formylcytosine, …
suggest that TET proteins could also be involved in the oxidation of 5-methylcytosine in …
suggest that TET proteins could also be involved in the oxidation of 5-methylcytosine in …
[HTML][HTML] The methylation game: epigenetic and epitranscriptomic dynamics of 5-methylcytosine
A Alagia, M Gullerova - Frontiers in Cell and Developmental Biology, 2022 - frontiersin.org
… Active demethylation is mediated by Ten-eleven Translocation (TET) dioxygenases. TET
enzymes oxidize 5-methylcytosine (m 5 C) to produce 5-hydroxymethylcytosine (hm 5 C), 5-…
enzymes oxidize 5-methylcytosine (m 5 C) to produce 5-hydroxymethylcytosine (hm 5 C), 5-…
The function and regulation of TET2 in innate immunity and inflammation
B Cong, Q Zhang, X Cao - Protein & cell, 2021 - academic.oup.com
… (TET) family as α-ketoglutarate- and Fe 2+ -dependent dioxygenase catalyzing the iterative
oxidation of 5-methylcytosine (… TET protein-mediated dynamic regulation of DNA methylation …
oxidation of 5-methylcytosine (… TET protein-mediated dynamic regulation of DNA methylation …
[HTML][HTML] Role of DNA De-methylation intermediate '5-hydroxymethylcytosine'in ovarian cancer management: a comprehensive review
… Global hypomethylation is defined as a decrease in 5-methylcytosine content … TET mediated
oxidation of methylated cytosine form to successive unmodified cytosines by the enzyme TET…
oxidation of methylated cytosine form to successive unmodified cytosines by the enzyme TET…
[HTML][HTML] Ten-eleven translocation proteins (TETs): tumor suppressors or tumor enhancers?
C Ma, H Seong, Y Liu, X Yu, S Xu, Y Li - Frontiers in Bioscience …, 2021 - imrpress.com
… 5-methylcytosine (5-mC) and its oxidative derivative, … via TET protein mediated
hydroxymethylation of the methylated promoter regions in the oncogenes, thereby TET functioning as …
hydroxymethylation of the methylated promoter regions in the oncogenes, thereby TET functioning as …
Known and unknown functions of TET dioxygenases: the potential of inducing DNA modifications in Epigenetic Editing
H Chen - 2021 - research.rug.nl
… that TET had catalytic activity in oxidizing 5-methylcytosine (… Ito et al. also found that TET
could further oxidize 5hmC to 5-… into adipocytes, TET protein-mediated DNA demethylation …
could further oxidize 5hmC to 5-… into adipocytes, TET protein-mediated DNA demethylation …
Regulation of TET2 gene expression and 5mC oxidation in breast cancer cells by estrogen signaling
… TET) proteins catalyze the conversion of 5-methylcytosine (5mC) to 5hmC/5fC/5caC, which
could function … The dysregulation of TET family genes and aberrant 5mC oxidation have been …
could function … The dysregulation of TET family genes and aberrant 5mC oxidation have been …