Insights into new mechanisms and models of cancer stem cell multidrug resistance

Y Garcia-Mayea, C Mir, F Masson, R Paciucci… - Seminars in cancer …, 2020 - Elsevier
… and resistant disease. Targeting resistant cancers is a major challenge in oncology; however…
and increase life expectancy, relapse and multidrug resistance (MDR) ultimately remain the …

[HTML][HTML] Anticancer drug resistance: An update and perspective

R Nussinov, CJ Tsai, H Jang - Drug Resistance Updates, 2021 - Elsevier
… discuss the molecular mechanisms underlying drug resistance while focusing on those
emerging to common targeted cancer drivers. We also address questions of why cancers with a …

Multidrug resistance in cancer: understanding molecular mechanisms, immunoprevention and therapeutic approaches

TB Emran, A Shahriar, AR Mahmud, T Rahman… - … in Oncology, 2022 - frontiersin.org
drug resistance mechanisms in cancer. Cancer cells develop resistance to anticancer
agents (drugs… Furthermore, EVs derived from drug-resistant cancer cells may also serve as …

Surmounting cancer drug resistance: New insights from the perspective of N6-methyladenosine RNA modification

B Li, J Jiang, YG Assaraf, H Xiao, ZS Chen… - Drug resistance …, 2020 - Elsevier
… In this review, we discuss the molecular mechanisms underlying the m 6 A modification in
regulating anticancer drug resistance through modulation of drug-target interaction and drug-…

Targeting MAPK signaling in cancer: mechanisms of drug resistance and sensitivity

S Lee, J Rauch, W Kolch - International journal of molecular sciences, 2020 - mdpi.com
drug sensitivity and resistance in cancer. We briefly discuss new findings in the extracellular
signaling-regulated kinase (ERK) pathway, but mainly focus on the mechanisms … of cancer

Challenges and opportunities in cancer drug resistance

RA Ward, S Fawell, N Floc'h, V Flemington… - Chemical …, 2020 - ACS Publications
… they can offer valuable insights into understanding the mechanism of resistance and how to
… In addition, some mutations which cause resistance can be from additional effects unrelated …

Epitranscriptomics and epiproteomics in cancer drug resistance: therapeutic implications

H Song, D Liu, S Dong, L Zeng, Z Wu, P Zhao… - Signal transduction and …, 2020 - nature.com
Drug resistance is a major hurdle in cancer treatment and a key cause … drug resistance. In
this review article, we summarized the recent progress in overcoming cancer drug resistance

Practical classification of triple-negative breast cancer: intratumoral heterogeneity, mechanisms of drug resistance, and novel therapies

A Marra, D Trapani, G Viale, C Criscitiello… - … breast cancer, 2020 - nature.com
… Furthermore, we point out current and emerging biomarker-driven treatments for TNBC
subtypes and describe the most common mechanisms of drug resistance for approved therapies …

Cancer drug resistance induced by EMT: novel therapeutic strategies

J De Las Rivas, A Brozovic, S Izraely, A Casas-Pais… - Archives of …, 2021 - Springer
… importance of tumour microenvironment and EMT in multidrug resistance (MDR), this issue
will … in depth into the molecular mechanism by which EMT induce therapy resistance and how …

Non-genetic mechanisms of therapeutic resistance in cancer

JC Marine, SJ Dawson, MA Dawson - Nature Reviews Cancer, 2020 - nature.com
… a | Genetic mechanisms of drug resistance include mechanismsinsights into the key
determinants that mediate neuroendocrine transformation in both lung cancer and prostate cancer, …