… role during the process of reverse transcription initiation in HIV-1. … Mechanisms involved
in the selection of HIV-1 reverse transcriptase thumb subdomain polymorphisms associated …

… The mechanism for other mutations involving residues that … the thumb and finger subdomains
have been associated with … In this work on HIV-1 reverse transcriptase protein, we have …

… polymorphisms associated with INSTI resistance in HIV-1 … subdomain, which is similar and
conserved in many reverse … will focus on HIV-1 reverse transcription, protease processing…

… domain of the RT.19, 27 The selected residues were also found at interacting sites with the
… hairpin in the thumb subdomain. The process of reverse transcription requires coordination …

… two copies of a zinc-finger domain that bind to unspliced viral … FIGURE 2.2 Reverse
transcription mechanism Viral RNA is … antigen (HLA) gene polymorphisms have been linked to the …

… HIV-1 RT is a heterodimer of the p66 and p51 subunits. The larger p66 subunit contains five
subdomains: fingers, palm, thumb, … the whole HIV-1 RT p66-p51 with the selected compound …

… gp120 resistance-associated polymorphisms at key sites … HIV-1 reverse transcriptase
enzyme and its approved NRTI … , and thumb subdomains of p66 and the thumb subdomain of …

… HIV-1 undergoes rapid genetic evolution owing to events in … and recombination during
reverse transcription and a rapid … into four subdomains; palms, fingers, connection, and thumb. …

… , HIV-1 reverse transcriptase (RT) transcribes HIV-1 RNA to a … The primer for HIV-1 reverse
transcription is tRNALys that is … , specific initiation of reverse transcription from the bound …

… that naturally occurring Gag polymorphisms in CRF02_AG and … HIV-1 life cycle and
involvement of host proteins .................... 36 Figure 1.6 The structure of HIV-1 Reverse Transcriptase …