… The error rates and mutation frequencies of HIV-1 reverse transcriptase (RT) are … reverse
transcriptase. Alanine scanning mutagenesis of an alpha-helix in the thumb subdomain. J. Biol. …

… Although the resistance mechanism involved remains … mutations while other polymorphisms
found in viruses selected under … of the connection subdomain in reverse transcription and its …

… by a virally encoded enzyme, reverse transcriptase, that is … We hypothesized that subdomains
within V3 determine coreceptor … Knowledge of the mechanism by which this strain of HIV-1 …

… Our results highlight the role of the fingers subdomain in … During HIV-1 reverse transcription,
strand displacement is … Amino acid substitutions emerging in HIV-1 RTs from virus selected …

… is the error prone enzyme reverse transcriptase (RT), an … Despite the 2nd finger domain
being of similar length as the … In p66, the known polymorphic mutation K103R (in the palm …

… Before the downloading process, we selected only drug-naïve … RT, reverse transcriptase
(440 aa). Dots in group M … also identified the natural polymorphisms that can be considered …

… By contrast, each person inherits about 100 polymorphic and … primed reverse transcription
(TPRT) priming mechanism: an … of the thumb helices compared with both HIV-1 and HERV-K. …

… The p66 fingers and thumb subdomains, and the RNase H … RT for the aptamer compared
to non-selected DNAs (~5 nM). … In an effort to further elucidate the mechanism of high-affinity …

… roles in understanding the mechanisms of catalysis, inhibition … multiple subdomains, and the
movement of the subdomains, … E138K is a non-polymorphic mutation selected in patients on …

… therapy (ART) for treatment of HIV-1 has been revolutionary in … ways, to help understand its
mechanism of action and develop … These libraries are excellent choices for small-scale XCFS …