In Vitro Analysis of HIV-1 Proteolytic Maturation Kinetics

R Sahm - 2021 - archiv.ub.uni-heidelberg.de
… by a specific release of subdomains inside the viral particle. … In the cytoplasm, the reverse
transcription of vRNA by the RT … If HIV-1 yields a mechanism for the lowering of pH and if the …

Structural and biochemical studies of orthomyxovirus nucleoproteins as targets of the antiviral Mx proteins

A Dick - 2022 - refubium.fu-berlin.de
… Investigating the antiviral mechanism of the IFNinduced Mx proteins was part of the
present … virus type-I (HIV-1) and other primate lentiviruses but not orthomyxoviruses (70-72). …

Meeting report: 36th international conference on antiviral research in Lyon, France, March 13–17, 2023

JR Spengler, K Carter, L Delang, D Durantel… - Antiviral Research, 2023 - Elsevier
… His group has selected darpins as a mechanism to direct agents directly and … HIV-1 reverse
transcriptase and DNA reveals its molecular mechanism of inhibition of reverse transcription. …

Transcriptional regulator BOB. 1: Molecular mechanisms and emerging role in chronic inflammation and autoimmunity

N Yeremenko, R Danger, D Baeten, A Tomilin… - Autoimmunity …, 2021 - Elsevier
… and POUh sub-domains, when these sub-domains belonging … Lupus OCT1 binding site
polymorphisms are associated with … in mice lacking the zinc finger transcription factor Aiolos (82) …

Host-Virus Interactions during ESCRT-Dependent Virus Budding

L Rheinemann - 2021 - search.proquest.com
… APOBEC3G interferes with reverse transcription in newly infected target cells by inducing …
Opposing mechanisms involving RNA and lipids regulate HIV-1 Gag membrane binding …

Engineering polymerases for applications in synthetic biology

A Nikoomanzar, N Chim, EJ Yik… - Quarterly reviews of …, 2020 - cambridge.org
… the O-helix of the finger subdomain that results in a partially … an enzyme with XNA reverse
transcriptase activity by solving … to distinguish single-nucleotide polymorphisms from random …

Jumping Ahead with Sleeping Beauty: Mechanistic Insights into Cut-and-Paste Transposition

MT Ochmann, Z Ivics - Viruses, 2021 - mdpi.com
… RED subdomain is involved in protein–protein interactions and forms dimers upon DNA
binding [36]. Helix 2 of the RED subdomain … Additional molecular mechanisms involved in the …

Drug design and repurposing with DockThor-VS web server focusing on SARS-CoV-2 therapeutic targets and their non-synonym variants

IA Guedes, LSC Costa, KB Dos Santos, ALM Karl… - Scientific Reports, 2021 - nature.com
… outbreak, the generations of polymorphic viral quasispecies can … and is folded into three
subdomains, namely thumb, palm, and … Lopinavir is another antiviral drug inhibitor of the HIV-1

[PDF][PDF] A comprehensive overview of Covid-19's cell biology effect mechanism: Variable Variants

H Koksoy - 2022 - earsiv.kmu.edu.tr
… of RNA between thumb subdomains and finger subdomains. The Palmar subdomain contains
the … nsp12 motifs F and G are located in the finger subdomain. It also has the function of …

Tripartite Motif 22 (TRIM22) protein restricts herpes simplex virus 1 by epigenetic silencing of viral immediate-early genes

TS Reddi, PE Merkl, SY Lim, NL Letvin… - PLoS …, 2021 - journals.plos.org
… well-established nuclear sub-domains that confer resistance to … polymorphisms (SNPs), which
have been shown to be … a decreased capacity to inhibit HIV-1 transcription [31]. Consistent …