Making sense of the natural antisense transcript puzzle

RS Reis, Y Poirier - Trends in Plant Science, 2021 - cell.com
… of antisense transcript action in gene regulation and suggest … and sense transcripts are
transcribed from the same genomic … RNA isolation and analysis also impact estimation of the cis-…

[HTML][HTML] Gene regulation by antisense transcription: A focus on neurological and cancer diseases

S Najafi, SC Tan, P Raee, Y Rahmati… - Biomedicine & …, 2022 - Elsevier
… This review outlines the involvements and mechanisms of NATs in the pathogenesis of …
roles in influencing the expression of essentially all genes in the genome, including those …

Fine chromatin-driven mechanism of transcription interference by antisense noncoding transcription

JK Gill, A Maffioletti, V García-Molinero, F Stutz… - Cell Reports, 2020 - cell.com
… Eukaryotic genomes are almost entirely transcribed by RNA … of natural antisense transcription
into gene promoters may … coding gene expression when noncoding transcription elongates …

Antisense-mediated transcript knockdown triggers premature transcription termination

JS Lee, JT Mendell - Molecular cell, 2020 - cell.com
… on gene expression through several different mechanisms. … These findings reveal
important considerations for the … Genome-wide profiling of RNA polymerase transcription at …

Natural antisense transcripts in the biological hallmarks of cancer: powerful regulators hidden in the dark

S Zhao, X Zhang, S Chen, S Zhang - Journal of Experimental & Clinical …, 2020 - Springer
… , affect multiple stages of gene expression, from epigenetic to post-… (NATs), based on their
original genomic locations or their … -sense RNA duplex may have a physical protective effect

HIV-1 natural antisense transcription and its role in viral persistence

R Li, R Sklutuis, JL Groebner, F Romerio - Viruses, 2021 - mdpi.com
… , sense and antisense transcripts originate from the same genomic locus, … gene expression
has to be high enough to oppose the repressive/buffering effect of the antisense transcript

DNA processing in the context of noncoding transcription

U Gowthaman, D García-Pichardo, Y Jin… - Trends in Biochemical …, 2020 - cell.com
… regulate host gene expression by a variety of mechanisms, … the biological significance of the
act of lncRNA transcription on … We divided ncRNAs according to their genomic location and …

Regulation of gene expression by cis-acting long non-coding RNAs

N Gil, I Ulitsky - Nature Reviews Genetics, 2020 - nature.com
effect on select genes can function over large genomic … It remains to be determined whether
this effect is direct (that is… promote target gene expression through various mechanisms 83 ) …

Regulatory R-loops as facilitators of gene expression and genome stability

C Niehrs, B Luke - Nature reviews Molecular cell biology, 2020 - nature.com
… enriched at genes associated with antisense transcription and … in vivo and the underlying
mechanism remain to be shown 60 … consequences of accumulated R-loops are on transcription

The regulatory role of antisense lncRNAs in cancer

B Liu, W Xiang, J Liu, J Tang, J Wang, B Liu… - Cancer cell …, 2021 - Springer
… for less than 2% of the human genome, whereas most of the … shows that antisense lncRNAs
exert their role on gene expressionAntisense lncRNAs have a crucial effect in the process of …