Computational Investigation into the Oxidation of Guanine to Form Imidazolone (Iz) and Related Degradation Products
SP Hebert, HB Schlegel - Chemical Research in Toxicology, 2020 - ACS Publications
… Cadet and co-workers investigated the mechanism for Iz formation via riboflavin photooxidation
… be formed by reaction of molecular oxygen with a transient intermediate radical, or as an …
… be formed by reaction of molecular oxygen with a transient intermediate radical, or as an …
Hydroxyl radical is predominantly involved in oxidatively generated base damage to cellular DNA exposed to ionizing radiation
J Cadet, D Angelov, JR Wagner - International Journal of …, 2022 - Taylor & Francis
… mechanism for the formation of 2Ih involving initial • OH addition to Gua at C5. This is
problematic for two … , it was found that one-electron oxidation reactions of nucleobases lead to a …
problematic for two … , it was found that one-electron oxidation reactions of nucleobases lead to a …
Theoretical insight into 7, 8-dihydrogen-8-oxoguanine radical cation deprotonation
S Wei, Z Zhang, S Liu, Y Wang - New Journal of Chemistry, 2021 - pubs.rsc.org
… G encounters hydroxyl radicals, singlet oxygen, or one-electron … the mechanisms of 8-oxoG
+ deprotonation reaction, 15 … This may be due to the fact that the hydration models built in …
+ deprotonation reaction, 15 … This may be due to the fact that the hydration models built in …
8-Oxoguanine: from oxidative damage to epigenetic and epitranscriptional modification
… hydroxyl radicals, superoxide, and hydrogen peroxide (H 2 O … quality control, and regulatory
mechanisms for redox-mediated … reaction, LSD1 generates local ROS (H 2 O 2 ) that lead to …
mechanisms for redox-mediated … reaction, LSD1 generates local ROS (H 2 O 2 ) that lead to …
On the relevance of hydroxyl radical to purine DNA damage
… Hydroxyl radicals (HO • ) are the most reactive species … reaction mechanism, involving the
production of HO • radical … , the DNA glycosylase which removes 8-oxoguanine in G:C pairs, a …
production of HO • radical … , the DNA glycosylase which removes 8-oxoguanine in G:C pairs, a …
DFT mechanistic study on the formation of 8-oxoguanine and spiroiminodihydantoin mediated by iron Fenton reactions
HY Chen, YF Lin - Dalton Transactions, 2021 - pubs.rsc.org
… Then, the detailed mechanisms of the formation of 8-oxoG and … reactions can lead to the
formation of 8-oxoG and Sp through multiple reaction pathways involving both OH radical and …
formation of 8-oxoG and Sp through multiple reaction pathways involving both OH radical and …
8-oxoguanine and 8-oxodeoxyguanosine Biomarkers of Oxidative DNA Damage: A Review on HPLC–ECD Determination
AM Chiorcea-Paquim - Molecules, 2022 - mdpi.com
… living cells due to metabolic and biochemical reactions and due to … lead to oxidative DNA
damage. Within ROS-mediated DNA lesions, 8-oxoguanine (8-oxoG) and its nucleotide 8-oxo-2…
damage. Within ROS-mediated DNA lesions, 8-oxoguanine (8-oxoG) and its nucleotide 8-oxo-2…
[HTML][HTML] On the epigenetic role of guanosine oxidation
M Giorgio, GI Dellino, V Gambino, PG Pelicci - Redox Biology, 2020 - Elsevier
… ways that lead to DNA oxidation and the regulation of mechanisms … In addition, the mechanisms
of 8-oxo-dG formation and … OH radical through a homolytic reaction, releasing both • OH …
of 8-oxo-dG formation and … OH radical through a homolytic reaction, releasing both • OH …
Chemistry of ROS-mediated oxidation to the guanine base in DNA and its biological consequences
AM Fleming, CJ Burrows - International journal of radiation biology, 2022 - Taylor & Francis
… two very different mechanisms, we show in Figure 2 the reaction of G with hydroxyl radical
vs… We show in Figure 2(A,B) that three mechanisms could lead to 8-hydroxyguanosine which …
vs… We show in Figure 2(A,B) that three mechanisms could lead to 8-hydroxyguanosine which …
Products of oxidative guanine damage form base pairs with guanine
K Kino, T Kawada, M Hirao-Suzuki… - International journal of …, 2020 - mdpi.com
… , and these base pairs can lead to GC transversions. In … forming base pairs are important
in the antiviral mechanisms against RNA viruses, some reaction products capable of forming …
in the antiviral mechanisms against RNA viruses, some reaction products capable of forming …