Role of specialized pro-resolving mediators in neuropathic pain

A Leuti, M Fava, N Pellegrini… - Frontiers in …, 2021 - frontiersin.org
… SPMs on neuropathic pain (A): SPMs modulate the genesis of neuropathic pain by acting on
… Chemical structure of the main SPMs involved in neuropathic pain (B). SPM receptors, with …

Mediators of neuropathic pain; focus on spinal microglia, CSF-1, BDNF, CCL21, TNF-α, Wnt ligands, and interleukin 1β

PA Boakye, SJ Tang, PA Smith - Frontiers in Pain Research, 2021 - frontiersin.org
… A variety of chemical mediators effect communication between the various cell types … of
pathological pain. We focus on mediators that affect spinal microglia, mediators released from …

Mechanisms for reducing neuropathic pain

DP Kuffler - Molecular Neurobiology, 2020 - Springer
… and mediators contributing to the development and maintenance of neuropathic pain are …
, inducing the release of anti-inflammatory mediators, and silencing the chronically electrically …

Neuroinflammation, oxidative stress and their interplay in neuropathic pain: Focus on specialized pro-resolving mediators and NADPH oxidase inhibitors as potential …

L Teixeira-Santos, A Albino-Teixeira, D Pinho - Pharmacological Research, 2020 - Elsevier
Neuropathic pain (NP) is a chronic condition that results from a lesion or disease of the …
of exogenous specialized pro-resolving mediators (SPMs) ameliorates NP pathophysiology. …

Pain-resolving immune mechanisms in neuropathic pain

NT Fiore, SR Debs, JP Hayes, SS Duffy… - Nature Reviews …, 2023 - nature.com
… In summary, an emerging picture indicates that specific innate immune cell subtypes and
associated mediators promote the resolution of neuropathic pain. Several processes are …

Neuropathic pain: from mechanisms to treatment

NB Finnerup, R Kuner, TS Jensen - Physiological reviews, 2021 - journals.physiology.org
… They subsequently reported that SOM+ neurons are largely sufficient and necessary to
mediate mechanical hypersensitivity in neuropathic pain (119). Peirs et al. (381) implicated a …

Anti-neuropathic pain activity of a cationic palladium (II) dithiocarbamate by suppressing the inflammatory mediators in paclitaxel-induced neuropathic pain model

M Naveed, R Ullah, A Khan, B Shal, AU Khan… - Molecular Biology …, 2021 - Springer
Neuropathic pain is a chronic pain state that negatively impacts the quality of life. Currently,
available therapies for the treatment of neuropathic pain often … suppress neuropathic pain. …

Peripheral neuropathic pain: from experimental models to potential therapeutic targets in dorsal root ganglion neurons

TY Yeh, IW Luo, YL Hsieh, TJ Tseng, H Chiang… - Cells, 2020 - mdpi.com
… In this review, we focus on molecular mechanisms and mediators of neuropathic pain
mediators and their modification and regulations provide excellent targets for neuropathic pain

Profiling of inflammatory mediators in the synovial fluid related to pain in knee osteoarthritis

L Li, Z Li, Y Li, X Hu, Y Zhang, P Fan - BMC Musculoskeletal disorders, 2020 - Springer
… of SF inflammatory mediators in neuropathic pain is not clear. … mediators associated with
nociceptive and neuropathic pain … between neuropathic pain and SF inflammatory mediators. …

[HTML][HTML] Neuromodulation, specialized proresolving mediators, and resolution of pain

X Tao, MS Lee, CR Donnelly, RR Ji - Neurotherapeutics, 2020 - Elsevier
… Recent studies suggest that SPMs inhibit inflammatory pain, postoperative pain, neuropathic
pain, and cancer pain in rodent models via immune, glial, and neuronal modulations. It is …