… to three representative antibiotics at increasingly heightened metabolic states. Doing so …
energy metabolism, which are implicated in antibiotic resistance. These mutations in metabolic …

… To address this challenge, we develop metabolic fitness models for resistance evolution …
as coupled perturbations of the cell’s metabolic network. A prominent example is illustrated in …

… Unlike genetic resistance to antibiotics (4), nongenetic resistance has a broad phylogenetic
… for nongenetic resistance to antibiotics. We posit that nongenetic antibiotic resistance results …

… between antibiotic resistance and tolerance. Subsequently, we discuss the close relationship
between bacterial metabolism and antibiotic tolerance. Based on this, bacterial metabolic …

… antibiotic resistance to develop effective approaches for the control. Here we explored the
metabolic difference between gentamicin-resistant V. … Metabolic regulation of VA-R GEN , …

… , metabolic function as well as ARGs via regulation of … the metabolic function; (4) understand
the relationships among ARGs, potential host bacteria for ARGs, and microbial metabolism. …

… the biofilm generate different metabolic states of individual … that govern antibiotic tolerance
and antibiotic resistance of … of both antibiotic tolerance and antibiotic resistance mechanisms. …

… 2.8 million antibiotic-resistant … to antibiotic resistance is projected to increase to as much
as 10 million deaths per year by 2050 if the problem is not kept in check and no new antibiotics …

… antibiotic research by pharmaceutical industries. This review summarized some new strategies
for tackling antibiotic resistance in … or approaches that block key metabolic pathways is a …

… antibiotic resistance to human and animal microbial flora. The currently implemented strategies
for overcoming antibiotic resistance … the product of the inhibited metabolic pathway [7,8]. …