Metabolic adaptations to infections at the organismal level

K Troha, JS Ayres - Trends in immunology, 2020 - cell.com
… These findings highlight an often-overlooked issue regarding the discussion on antibiotics
overuse: antibiotic misuse not only drives the rise of antibiotic resistance in pathogens, but it …

Evolving MRSA: High-level β-lactam resistance in Staphylococcus aureus is associated with RNA Polymerase alterations and fine tuning of gene expression

VV Panchal, C Griffiths, H Mosaei, B Bilyk… - PLoS …, 2020 - journals.plos.org
antibiotic resistance mechanisms and core cell physiology, providing new insight into how
such important resistance … effect of mecA acquisition on central metabolism and sheds light on …

Antibiotic Resistance Profiles, Molecular Mechanisms and Innovative Treatment Strategies of Acinetobacter baumannii

CO Vrancianu, I Gheorghe, IB Czobor, MC Chifiriuc - Microorganisms, 2020 - mdpi.com
… forms with a minimal metabolic rate, the treatment … antibiotic resistance profiles of A.
baumannii strains, the main mechanisms (enzymatic and non-enzymatic) of antibiotic resistance

Pathogenic and indigenous denitrifying bacteria are transcriptionally active and key multi-antibiotic-resistant players in wastewater treatment plants

L Yuan, Y Wang, L Zhang, A Palomo… - Environmental …, 2021 - ACS Publications
… ∼60% of all antibiotic resistance activities detected in the … as active and key players of
antibiotic resistance in WWTPs. … antibiotic resistance and nitrogen-removing metabolism in …

[HTML][HTML] Convergence of biofilm formation and antibiotic resistance in Acinetobacter baumannii infection

S Roy, G Chowdhury, AK Mukhopadhyay… - Frontiers in …, 2022 - frontiersin.org
… (QQ) molecules to facilitate biofilm matrix formation; indirect regulation of genes involved
in biofilm formation and efflux of antibiotics or metabolic intermediates (106, 107). There are …

Molecular reprogramming and phenotype switching in Staphylococcus aureus lead to high antibiotic persistence and affect therapy success

M Huemer, S Mairpady Shambat… - Proceedings of the …, 2021 - National Acad Sciences
… Given the increasing prevalence of antibiotic resistance and … phenotypic heterogeneity
underlying antibiotic persistence and … -regulation of amino acid metabolic proteins and nucleotide …

[HTML][HTML] Antibiotic resistance in microbes: History, mechanisms, therapeutic strategies and future prospects

TM Uddin, AJ Chakraborty, A Khusro… - Journal of infection and …, 2021 - Elsevier
… history of antibiotics, global strategies regarding this threat, mechanism of action of antibiotics
as well as antibiotic resistance to … inhibit different steps in folic acid metabolic pathway [77]. …

Thymine sensitizes gram-negative pathogens to antibiotic killing

Y Liu, K Yang, Y Jia, J Shi, Z Tong, Z Wang - Frontiers in Microbiology, 2021 - frontiersin.org
… design of novel drugs are urgently needed to confront antibiotic resistance crisis. There is
increasing evidence that the metabolic state of bacteria has an effect on their susceptibility to …

Incidence of antibiotic resistance in Vibrio spp

KY Loo, V Letchumanan, JWF Law… - Reviews in …, 2020 - Wiley Online Library
… of antibiotic patterns of Vibrio are important for clinical treatment. This review focuses on
different trends and global patterns of antibiotic resistance of … to curb this antibiotic resistance. …

Multidrug adaptive resistance of Pseudomonas aeruginosa swarming cells

SR Coleman, T Blimkie, R Falsafi… - Antimicrobial agents …, 2020 - Am Soc Microbiol
… , we sought to elucidate the mechanism(s) of swarming-mediated antibiotic resistance by …
its operon wbpZ-rmd), and nitrous oxide metabolism (where the nosZDF genes were 16.0- to …