… data indicated that GSH is important to prevent covalent binding and development of
hepatotoxicity. … Finally, the amount of protein binding correlates with the relative hepatotoxicity. …

… Thus, despite the substantial progress in understanding the mechanisms of APAP
hepatotoxicity, there are significant gaps in our knowledge that require more research. …

… Acetaminophen (APAP) overdose is the clinically most relevant drug hepatotoxicity in western
… This review covers intracellular signaling events starting with drug metabolism and the …

… molecular mechanisms of acetaminophen (APAP) hepatotoxicity began in 1973 to 1974, …
about APAP hepatotoxicity in humans so far. Overall, the mechanisms of APAP hepatotoxicity in …

… of toxicity of acetaminophen poisoning (metabolic and oxidative phase) and how this relates
to … Many fundamental mechanisms of acetaminophen hepatotoxicity observed in mice have …

… APAP metabolism The pathophysiological events of APAP hepatotoxicity have been well …
In fact, drug metabolism and disposition studies demonstrated that the majority of APAP is …

… Mechanistic insights into the hepatotoxicity of various drugs such as acetaminophen (APAP)
have spurred interest in using damage-associated molecular patterns (DAMPs) as …

… the drug-induced hepatotoxicity mechanisms and the … for the classical hepatotoxic drugs
paracetamol (acetaminophen), … disposition and for assessing the underlying mechanisms of …

… This review discusses common pitfalls in studies of acetaminophen hepatotoxicity. Image 1
… hepatotoxicity is a significant clinical problem. When a mouse model of APAP hepatotoxicity …

… Hepatic APAP metabolism is recognized as having a key role in the development of
hepatotoxicity. APAP is extensively metabolized by conjugation events upon exposure to low doses, …