Methionine metabolism in chronic liver diseases: an update on molecular mechanism and therapeutic implication

Z Li, F Wang, B Liang, Y Su, S Sun, S Xia… - Signal transduction and …, 2020 - nature.com
… reducing disease severity (Table 1). However, clinical research on methionine supplementation
… and pathophysiological roles of methionine metabolism in liver diseases, from molecular …

Association of serum methionine metabolites with non-alcoholic fatty liver disease: a cross-sectional study

Y Tang, X Chen, Q Chen, J Xiao, J Mi, Q Liu, Y You… - … & metabolism, 2022 - Springer
… as the leading chronic liver disease and a significant … methionine metabolism is highly
active in the hepatocytes and serum methionine levels were correlated with hepatic methionine

Methionine supplementation affects metabolism and reduces tumor aggressiveness in liver cancer cells

F Tripodi, B Badone, M Vescovi, R Milanesi, S Nonnis… - Cells, 2020 - mdpi.com
… ) infection or by alcoholic liver diseases and non-alcoholic steatohepatitis (… methionine
metabolism in the liver is very peculiar, since the liver is the organ where most of the methionine

[HTML][HTML] One-carbon metabolism in fatty liver disease and fibrosis: one-carbon to rule them all

P da Silva Robin, D Rafael - The Journal of nutrition, 2020 - Elsevier
… might offer benefits in fatty liver disease (96). However, other studies suggest that elevated
AdoMet may be pathological in NASH and methionine restriction should be considered (97). …

Thiamethoxam induces nonalcoholic fatty liver disease in mice via methionine metabolism disturb via nicotinamide N-methyltransferase overexpression

D Yang, X Zhang, L Yue, H Hu, X Wei, Q Guo, B Zhang… - Chemosphere, 2021 - Elsevier
… deficiency, and methionine metabolism disorder were also observed in TMX-treated
mouse livers. These results suggest that chronic TMX exposure induces dyslipidemia and …

The role of the transsulfuration pathway in non-alcoholic fatty liver disease

MP Werge, A McCann, ED Galsgaard, D Holst… - Journal of clinical …, 2021 - mdpi.com
NAFLD are limited, but changes in the sulfur metabolism, especially methionine metabolism,
in alcoholic liver disease … the TSP and histopathology in alcoholic liver disease (ALD) found …

[HTML][HTML] One-carbon metabolism and nonalcoholic fatty liver disease: the crosstalk between nutrients, microbiota, and genetics

A Radziejewska, A Muzsik, FI Milagro, JA Martínez… - Lifestyle …, 2020 - karger.com
Methionine is one of the major dietary sources of methyl donor groups [… that methionine
deficiency induces steatosis or fatty liver disease in a … Methionine metabolism in liver diseases

Maternal high‐fat diet disrupted one‐carbon metabolism in offspring, contributing to nonalcoholic fatty liver disease

H Peng, H Xu, J Wu, J Li, Y Zhou, Z Ding… - Liver …, 2021 - Wiley Online Library
… maternal HF diet disrupted the methionine cycle and one-carbon metabolism in offspring …
Multiple pathways were identified that are involved in folate and methionine metabolism

A comparison of the gene expression profiles of non-alcoholic fatty liver disease between animal models of a high-fat diet and methionine-choline-deficient diet

MA Alshawsh, A Alsalahi, SA Alshehade, SAM Saghir… - Molecules, 2022 - mdpi.com
… Non-alcoholic fatty liver disease (NAFLD) embraces several forms of liver disorders involving
fat disposition in hepatocytes ranging from simple steatosis to the severe stage, namely, …

HNF4α regulates sulfur amino acid metabolism and confers sensitivity to methionine restriction in liver cancer

Q Xu, Y Li, X Gao, K Kang, JG Williams, L Tong… - Nature …, 2020 - nature.com
methionine metabolism in colorectal PDX tumors and liver … DL-methionine and no cystine
suppresses liver cancer growth in a diethylnitrosamine (DEN)/high-fat-diet (HFD)-induced liver