… SAR, for Structure-Activity-Relationships. In the early days of … methylation and the two work
in concert: Histone methylation … that lead to neurofibrillary tangles and the pathological effects …

… axons which forms intracellular neurofibrillary tangles (NFTs) [1]. … effect of methylation on
Tau phosphorylation, methylation may … to be in inverse relation to the extent of methylation [24]. …

… phosphorylation of tau protein Its association with NFTs is more apparent in the initial disease
stage Promoter methylation … a more causal relationship between DNA methylation and the …

… A crosstalk between methylation and phosphorylation has … p53 lysine methylation was mostly
studied in relation to rapidly … the presence of intracellular neurofibrillary tangles (NFTs) of …

… to the markers of neurofibrillary tangles in neurons of patients … The relationship between DNA
methylation, pathogenesis … been correlated with eIF4E phosphorylation in both human and …

… a phosphorylated or acetylated residue (% of total methylated … possible temporal relationship
regulating the activity of PLK1. … Neurofibrillary tangles are caused by the agglomeration of …

… in AD neurons with neurofibrillary tangles 46 . … catalytic subunit of PP2A is phosphorylated
at the C-terminus … a conserved regulatory relationship between C-terminal methylation and …

… such as acetylation, methylation, or phosphorylation occur at … For example, the acetylation
and methylation of basic … compared to those for phosphorylation and ubiquitination implies the …

… a relationship between memory loss and FA due to an imbalance in DNA methylation and
… well characterized, including methylation, acetylation, and phosphorylation. Among them, …

… modifications include methylation, acetylation, phosphorylation, … Most histone methylation
and acetylation happen at the … s stress response in relation to changes in the methylation of the …