Analysis of blood methylation quantitative trait loci in East Asians reveals ancestry-specific impacts on complex traits

Q Peng, X Liu, W Li, H Jing, J Li, X Gao, Q Luo… - Nature Genetics, 2024 - nature.com
… In 12/16 hotspots, we found the index mQTLs or their high LD SNPs (r 2 > 0.6; … from 336
distinct loci throughout the genome (Table 1), which is largely consistent with the findings in …

Incorporating local ancestry improves identification of ancestry-associated methylation signatures and meQTLs in African Americans

B Li, BE Aouizerat, Y Cheng, K Anastos… - Communications …, 2022 - nature.com
… , we identified 36 methylation quantitative trait loci (meQTL) … Using principal component
analysis (PCA), we found that the … is consistent with our findings that the identified methylation

Genome-wide sequencing-based identification of methylation quantitative trait loci and their role in schizophrenia risk

KA Perzel Mandell, NJ Eagles, R Wilton… - Nature …, 2021 - nature.com
… being part of methylation quantitative trait loci (meQTLs). … , and we found that batch and
ancestry cause much variance in … are largely consistent with previous work, in that meQTLs are …

meQTL mapping in the GENOA study reveals genetic determinants of DNA methylation in African Americans

L Shang, W Zhao, YZ Wang, Z Li, JJ Choi… - Nature …, 2023 - nature.com
… commonly referred to as methylation quantitative trait locus (meQTL) mapping, … well-powered
meQTL mapping studies in populations with African ancestry can … Consistent with refs. , we …

Genetic control of DNA methylation is largely shared across European and East Asian populations

AA Hatton, FF Cheng, T Lin, RJ Shen, J Chen… - Nature …, 2024 - nature.com
… have been identified through DNAm quantitative trait loci (mQTL) … We investigated whether
this was consistent between … the gain in resolution for cross-ancestry fine mapping. We …

Genetic variation influencing DNA methylation provides insights into molecular mechanisms regulating genomic function

JS Hawe, R Wilson, KT Schmid, L Zhou… - … genetics, 2022 - nature.com
… associations (methylation quantitative trait loci (meQTL), P < … ) in both ancestry-specific and
cross-ancestry replication testing … We also show that 72–86% of our meQTL have a consistent

Genetic impacts on DNA methylation: research findings and future perspectives

S Villicaña, JT Bell - Genome biology, 2021 - Springer
Methylation quantitative trait loci, or meQTLs, allow for the … familial clustering studies are
consistent with those obtained … of European descent from the Brisbane System Genetics Study. …

Molecular quantitative trait loci

F Aguet, K Alasoo, YI Li, A Battle, HK Im… - Nature Reviews …, 2023 - nature.com
… self-reported ancestry, as … methylated cytosines at targeted sites across the genome (currently
available arrays target more than 850,000 sites). This has enabled meQTL studies across

Widespread methylation quantitative trait loci and their role in schizophrenia risk

KA Perzel Mandell, NJ Eagles, R Wilton, AJ Price… - bioRxiv, 2020 - biorxiv.org
… -wide methylation quantitative trait locus (meQTL) analyses (… , and we found that batch and
ancestry cause much variance … are largely consistent with previous work, in that meQTLs are …

Methylation Quantitative Trait Loci Associated with PTSD in a South African Population

M Du Plessis - 2021 - scholar.sun.ac.za
… tended to be found in one particular ancestry subset, with … few findings consistently replicate
across independent studies, several … accurately capturing the diverse ancestry of our sample …