Analysis of blood methylation quantitative trait loci in East Asians reveals ancestry-specific impacts on complex traits
… In 12/16 hotspots, we found the index mQTLs or their high LD SNPs (r 2 > 0.6; … from 336
distinct loci throughout the genome (Table 1), which is largely consistent with the findings in …
distinct loci throughout the genome (Table 1), which is largely consistent with the findings in …
Incorporating local ancestry improves identification of ancestry-associated methylation signatures and meQTLs in African Americans
… , we identified 36 methylation quantitative trait loci (meQTL) … Using principal component
analysis (PCA), we found that the … is consistent with our findings that the identified methylation …
analysis (PCA), we found that the … is consistent with our findings that the identified methylation …
Genome-wide sequencing-based identification of methylation quantitative trait loci and their role in schizophrenia risk
KA Perzel Mandell, NJ Eagles, R Wilton… - Nature …, 2021 - nature.com
… being part of methylation quantitative trait loci (meQTLs). … , and we found that batch and
ancestry cause much variance in … are largely consistent with previous work, in that meQTLs are …
ancestry cause much variance in … are largely consistent with previous work, in that meQTLs are …
meQTL mapping in the GENOA study reveals genetic determinants of DNA methylation in African Americans
… commonly referred to as methylation quantitative trait locus (meQTL) mapping, … well-powered
meQTL mapping studies in populations with African ancestry can … Consistent with refs. , we …
meQTL mapping studies in populations with African ancestry can … Consistent with refs. , we …
Genetic control of DNA methylation is largely shared across European and East Asian populations
… have been identified through DNAm quantitative trait loci (mQTL) … We investigated whether
this was consistent between … the gain in resolution for cross-ancestry fine mapping. We …
this was consistent between … the gain in resolution for cross-ancestry fine mapping. We …
Genetic variation influencing DNA methylation provides insights into molecular mechanisms regulating genomic function
… associations (methylation quantitative trait loci (meQTL), P < … ) in both ancestry-specific and
cross-ancestry replication testing … We also show that 72–86% of our meQTL have a consistent …
cross-ancestry replication testing … We also show that 72–86% of our meQTL have a consistent …
Genetic impacts on DNA methylation: research findings and future perspectives
S Villicaña, JT Bell - Genome biology, 2021 - Springer
… Methylation quantitative trait loci, or meQTLs, allow for the … familial clustering studies are
consistent with those obtained … of European descent from the Brisbane System Genetics Study. …
consistent with those obtained … of European descent from the Brisbane System Genetics Study. …
Molecular quantitative trait loci
… self-reported ancestry, as … methylated cytosines at targeted sites across the genome (currently
available arrays target more than 850,000 sites). This has enabled meQTL studies across …
available arrays target more than 850,000 sites). This has enabled meQTL studies across …
Widespread methylation quantitative trait loci and their role in schizophrenia risk
KA Perzel Mandell, NJ Eagles, R Wilton, AJ Price… - bioRxiv, 2020 - biorxiv.org
… -wide methylation quantitative trait locus (meQTL) analyses (… , and we found that batch and
ancestry cause much variance … are largely consistent with previous work, in that meQTLs are …
ancestry cause much variance … are largely consistent with previous work, in that meQTLs are …
Methylation Quantitative Trait Loci Associated with PTSD in a South African Population
M Du Plessis - 2021 - scholar.sun.ac.za
… tended to be found in one particular ancestry subset, with … few findings consistently replicate
across independent studies, several … accurately capturing the diverse ancestry of our sample …
across independent studies, several … accurately capturing the diverse ancestry of our sample …