Synthesis of Reactive Sulfur Species in Cultured Vascular Endothelial Cells after Exposure to TGF-β1: Induction of Cystathionine γ-Lyase and Cystathionine β …

M Takahashi, T Fujie, T Nakano, T Hara… - International journal of …, 2021 - mdpi.com
… Additionally, we revealed that fibroblast growth factor-2 (FGF-2) increases intracellular RSS
… functions by growth factors/cytokines via the induction of specific RSS-producing enzymes. …

Methionine Restriction Prevents Lipopolysaccharide-Induced Acute Lung Injury via Modulating CSE/H2S Pathway

J Duan, L Xiang, Z Yang, L Chen, J Gu, K Lu, D Ma… - Nutrients, 2022 - mdpi.com
… Unlike the majority of vital organs, the lung is directly open to the air and constantly exposed
to pathogens, allergens, irritants, and toxins; thus, in general, the lung has a high risk of …

Gasping for sulfide: a critical appraisal of hydrogen sulfide in lung disease and accelerated aging

D Pacitti, CJ Scotton, V Kumar, H Khan… - Antioxidants & Redox …, 2021 - liebertpub.com
… −/− mice manifested fibrotic injuries and air space enlargement in the lungs, with increased
… most for up to 5 weeks after birth with severe growth retardation (225). However, Hamelet et …

Host cystathionine-γ lyase derived hydrogen sulfide protects against Pseudomonas aeruginosa sepsis

G Renieris, DE Droggiti, K Katrini, P Koufargyris… - PLoS …, 2021 - journals.plos.org
… H 2 S concentrations and survival was assessed in septic patients with lung infection. … mice
with a constitutive knock-out of cystathionine-γ lyase (Cse) gene (Cse -/- ) and wild-type mice

Supersulphides provide airway protection in viral and chronic lung diseases

T Matsunaga, H Sano, K Takita, M Morita… - Nature …, 2023 - nature.com
lungs and in chronic lung diseases, including chronic obstructive pulmonary disease (COPD),
idiopathic pulmonary fibrosis (… growth in the lung significantly increased in Cars2 +/− mice

Proteomic exploration of cystathionine β-synthase deficiency: implications for the clinic

H Jakubowski - Expert Review of Proteomics, 2020 - Taylor & Francis
Introduction: Homocystinuria due to cystathionine β-synthase (CBS) deficiency, the most
frequent inborn error of sulfur amino acid metabolism, is characterized biochemically by …

[HTML][HTML] Hydrogen sulfide attenuates cigarette smoke-induced airway remodeling by upregulating SIRT1 signaling pathway

R Guan, J Wang, Z Cai, Z Li, L Wang, Y Li, J Xu, D Li… - Redox Biology, 2020 - Elsevier
… Airway remodeling is one of the characteristics for chronic obstructive pulmonary disease (…
epithelial cells via release and autocrine action of transforming growth factor (TGF)-β1 as well …

Hydrogen sulfide attenuates particulate matter-induced emphysema and airway inflammation through Nrf2-dependent manner

G Jia, S Yu, W Sun, J Yang, Y Wang, Y Qi… - Frontiers in …, 2020 - frontiersin.org
… Chronic obstructive pulmonary disease (COPD) is a disease characterized … spaces
enlargement and alveolar walls destrection (Bracke et al., 2006). The enlargement of alveolar …

Hydrogen sulfide alleviates cigarette smoke-induced COPD through inhibition of the TGF-β 1/smad pathway

L Wang, J Meng, C Wang, C Yang… - Experimental …, 2020 - journals.sagepub.com
pulmonary disease have not been reported. In this study, rats were treated with cigarette
smoke to create a chronic obstructive pulmonary disease … the transforming growth factor super …

Cystathionine βSynthase Regulates the Proliferation, Migration, and Invasion of Thyroid Carcinoma Cells

QY Jiang, JM Li, MR Jing, YX Zhang… - Oxidative Medicine …, 2022 - Wiley Online Library
… TPC-1 and ARO cells are widely adopted to establish subcutaneous xenograft tumor
models in nude mice [20, 36]. We then determined the effects of CBS on the growth of human …