Experimental Models in Parkinson's Disease: Advantages and Disadvantages

…, Z Al-yaqoobi, F Burul, C Bayram, S Sezen… - Ağrı Tıp Fakültesi … - dergipark.org.tr
… While 6-OHDA cannot mimic all aspects of the disease, it appears to be a replica of PD in
humans. … However, some drawbacks of using rotenone in PD modeling include the lack of well-…

[HTML][HTML] Is activation of GDNF/RET signaling the answer for successful treatment of Parkinson's disease? A discussion of data from the culture dish to the clinic

JA Conway, ER Kramer - Neural Regeneration Research, 2022 - journals.lww.com
Parkinson's disease patients, which mainly focused on optimizing the GDNF delivery technique,
benefits … It is speculated that BT13 mimics soluble GDNF/GFRα1, rather than GDNF itself…

[HTML][HTML] Cell models for Alzheimer's and Parkinson's disease: At the interface of biology and drug discovery

S Cetin, D Knez, S Gobec, J Kos, A Pišlar - Biomedicine & …, 2022 - Elsevier
… information about the therapeutic benefits of drugs under development. … This hallmark is
used in the development of models that mimic the … The major pros and cons of cell models in …

[图书][B] Rethinking Parkinson's Disease: The definitive guide to the known causes of Parkinson's disease and proven reversal strategies

JC Coleman - 2020 - books.google.com
dish with a particular mould were dead. Instead of ignoring … Advantages of Western allopathic
medicine treatment for … effects mimicking one or more symptoms of Parkinsons disease. …

[HTML][HTML] Microglia in a dish—which techniques are on the menu for functional studies?

P Aktories, P Petry, K Kierdorf - Frontiers in Cellular Neuroscience, 2022 - frontiersin.org
… models is wide and they come with different advantages and … organotypic environment by
mimicking direct interactions … specific neurological disorder like Parkinsons disease and then …

[HTML][HTML] Current state-of-the-art and unresolved problems in using human induced pluripotent stem cell-derived dopamine neurons for parkinson's disease drug …

SA Antonov, EV Novosadova - International Journal of Molecular …, 2021 - mdpi.com
… The introduction of 3D culture methods to mimic the brain … However, while the benefits for
basic and applied studies … the floor plate genes is apparently the most widely used method for …

[HTML][HTML] In vitro Models of Neurodegenerative Diseases

A Slanzi, G Iannoto, B Rossi, E Zenaro… - Frontiers in cell and …, 2020 - frontiersin.org
… , mimicking neuronal and glial cell interactions, and incorporating the effects of blood flow. In
this review, we discuss the relative merits of … bioreactor with a microtiter plate format. Within …

[HTML][HTML] A critical review of zebrafish models of Parkinson's disease

JM Doyle, RP Croll - Frontiers in Pharmacology, 2022 - frontiersin.org
… The end goal of this review is to determine the benefits of using zebrafish in comparison to
utilising … No animal model can perfectly mimic human disease, especially highly complex …

Clinical and Imaging Pitfalls in the Diagnosis of Idiopathic Parkinson's Disease 237

A Chakravarty - … in the Diagnosis of Neurological Disorders, 2022 - books.google.com
used commonly, is somewhat controversial. While some authors have suggested that different
disorders mimicking … and metabolic disorders may cause tremors which merit mentioning. …

[HTML][HTML] Comprehensive perspectives on experimental models for Parkinson's disease

M Ke, CM Chong, Q Zhu, K Zhang, CZ Cai… - … and disease, 2021 - ncbi.nlm.nih.gov
… Pigs have the advantages for mimicking human disease due to their unique features
exhibiting not only high homology of human genes but also similarities in anatomy, metabolism, …