Advances in Neuropathic Pain Research: Selected Intracellular Factors as Potential Targets for Multidirectional Analgesics

K Ciapała, J Mika - Pharmaceuticals, 2023 - mdpi.com
… ) or pain caused by physiologically painless stimuli (allodynia) … and PD98059 [22] potentiate
morphine and/or buprenorphine … in detail the importance of minocycline, astaxanthin, fisetin, …

A neuroprotective effect of pentoxifylline in rats with diabetic neuropathy: Mitigation of inflammatory and vascular alterations

RAM Salama, FA Raafat, AH Hasanin… - International …, 2024 - Elsevier
… Tactile allodynia was less in rats that received pentoxifylline at … of PTX and elucidate its
underlying potential to attenuate … ANOVA], with a significant increase of blood glucose level over …

Minocycline and doxycycline: more than antibiotics

S Singh, D Khanna, S Kalra - Current Molecular Pharmacology, 2021 - ingentaconnect.com
Minocycline-treated group significantly potentiated anti-allodynic and anti-hyperalgesic effect
… of LvOn-si-TLR4 with doxycycline attenuated allodynia and hyperalgesia, in a rat model of …

… behaviors by Inhibiting the microglial/macrophage activation, p38MAPK signaling, and pronociceptive CCL2 and CCL5 release in a mouse model of neuropathic pain

R Zajączkowska, K Pawlik, K Ciapała, A Piotrowska… - Pharmaceuticals, 2023 - mdpi.com
effect of pregabalin and mirogabalin in a neuropathic pain … 40 mg/kg, significantly attenuating
tactile hypersensitivity [F (3, … Sciatic nerve injury led to an increase of protein levels of …

Brief research report: Repurposing pentoxifylline to treat intense acute swimming–Induced delayed-onset muscle soreness in mice: Targeting peripheral and spinal …

SM Borghi, TH Zaninelli, T Saraiva-Santos… - Frontiers in …, 2023 - frontiersin.org
… In this study, we pursue determining the effect of pentoxifylline (… An increase of CK levels in
the blood is a characteristic of … By inhibiting TNF-α production, Ptx can reduce inflammation, …

[HTML][HTML] Licofelone, a Dual COX/LOX Inhibitor, Ameliorates Paclitaxel-Induced Mechanical Allodynia in Rats in a Cannabinoid Receptor-Dependent Manner

W Masocha, E Aly, A Albaloushi, A Al-Romaiyan - Biomedicines, 2024 - mdpi.com
… of indomethacin plus minocycline (IPM) attenuates PINP in a … have potentiated antinociceptive
activity in models of acute pain [… a synergistic effect of indomethacin and minocycline when …

… effects of fisetin, peimine, astaxanthin, artemisinin, bardoxolone methyl and 740 YP and their influence on opioid analgesia in a mouse model of neuropathic pain

K Ciapała, E Rojewska, K Pawlik… - International Journal of …, 2023 - mdpi.com
minocycline, which, apart from being a p38 inhibitor, also impairs ERK1/2 and JNK signaling
[53,54]. To date, minocycline has been shown to reduce … relieves pain, it does not increase

[PDF][PDF] Inflammatory and Post-inflammatory Nociception in a Model of Arthritis

B Allen - 2022 - kclpure.kcl.ac.uk
pain by recapitulating clinical and pathological features of the human condition provide an
important tool for delineating mechanisms contributing to pain in … , persistent hyperalgesia that …

Pharmacologic agents directed at the treatment of pain associated with maladaptive neuronal plasticity

JV Pergolizzi Jr, G Varrassi, P Magnusson… - Expert opinion on …, 2022 - Taylor & Francis
… -term antidepressant therapy potentiates the effects of BDNF. … have been shown to reduce
mechanical allodynia [Citation43]… In a murine study, minocycline modulated BDNF and in that …

Effect of pharmacological modulation of the kynurenine pathway on pain-related behavior and opioid analgesia in a mouse model of neuropathic pain

K Ciapała, K Pawlik, A Ciechanowska, J Mika… - Toxicology and Applied …, 2023 - Elsevier
… Additionally, we observed the attenuation of pain-related … L-KYN preceded by the injection
of minocycline, an inhibitor of … that UPF648 potentiated the analgesic effect of morphine and …