… In particular, minocycline has been shown to directly target … -dependent or caspase-independent
mechanisms. Also, it has … to assess the efficacy of minocycline in improving neurologic …

… induction of spinal cord injury; however, no … minocycline in treatment of SCI, we aimed to
investigate its prophylactic effects and their underlying mechanisms in a rat model of spinal cord …

… Traumatic spinal cord injury (TSCI) induces a powerful … and severity of neural damage (termed
as “secondary injury”). Thus… and release kinetics at the injury site. This study describes the …

… that minocycline given intravenously within 12 h and 7 days resulted in steady-state serum
concentrations reaching the target … Chronic spinal cord lesion usually leads to the formation of …

… These antibiotics may target similar signaling pathways such … in spinal cord lesions, though
the underlying mechanism is … these mechanisms and demonstrated that minocycline could …

… expressed in the spinal cord tissues of the minocycline group and the model group. At 3 d,
7 d, 14 d, 21 d and 28 d after operation, the expression of BDNF in the minocycline group was …

… The intervention group (MPMC) received a bolus infusion of MP 30 mg/kg in 15 min
intravenously, followed by a 5.4 mg/kg infusion of MP for 24–48 h and 50 mg Minocycline orally …

… is a premier therapeutic target to improve functional outcomes (… This study showed that
minocycline therapy was safe and … IL-1β in the spinal cord lesion), inhibits glutamate excitotoxicity, …

… nerve cell loss, which can result in motor deficiencies [21]. Therefore, apoptosis represents
an important therapeutic target for TBI. A series of animal studies have confirmed that …

… water content elevation and tissue edema after spinal cord injury 48 . AQP4 down-regulation …
Our current study led us to identify AQP4 as a new target for minocycline treatment in TBI, …