… of the heart and skeletal muscle. Numerous gene replacement … We also detected a trend
of reduction in the serum creatine … by modulating SERCA activity or expressing more SERCA. …

… (18) showed that transgenic SERCA overexpression … male mice for 10 months mitigated
age-related muscular atrophy and … mdx mice, which actively regenerate injured skeletal muscle. …

… , overexpression of SERCA protein or deletion of the SERCA … in skeletal muscles of mice
with muscular dystrophies [12]. In … in signaling pathways controlling skeletal muscle mass. This …

… , and muscular dystrophy (MD) significantly depress SERCA … overexpression of catalase
targeted to skeletal muscle mitochondria (mMCAT) in the Sod1KO mouse muscle atrophy …

… Sarco/endoplasmic reticulum calcium ATPase (SERCA) is a … While the data from mdx
mice are highly promising, it is … a significant reduction in AAV-injected muscles (Figure 2C). …

… studies on improving SERCA function as a strategy to mitigate skeletal muscle disease and
… effects of SERCA overexpression in ameliorating muscular dystrophy in mice (Morine et al., …

… in skeletal muscle of WT/+SERCA and ALS-Tg/+SERCA mice and that both returned to
normal WT levels in ALS-Tg/+SERCA1 … Mitigation of muscular dystrophy in mice by SERCA …

… role of PLN-mediated SERCA regulation in DMD skeletal muscle pathology has yet to be
studied, PLN overexpression in murine skeletal muscle causes severe muscle atrophy and a …

… been achieved by SERCA overexpression or knockdown of … improve SERCA function and
mitigate DMD cardiomyopathy. … ameliorate dystrophic skeletal muscle disease in mice, and …

… Serca1 overexpression in skeletal muscle, and one study looked at Serca2a overexpression
in the heart of different mouse … Similar to PLN, sarcolipin (SLN) is an inhibitor of Serca. SLN …