Nitric oxide and dopamine metabolism converge via mitochondrial dysfunction in the mechanisms of neurodegeneration in Parkinson's disease

C Nunes, J Laranjinha - Archives of Biochemistry and Biophysics, 2021 - Elsevier
cell death via mechanisms that involve mitochondrial dysfunction, gluthathione depletion
and nitroxidative stress. … the neuronal death that occurs in the neurodegenerative diseases. …

Mitochondrial dysfunction as a signaling target for therapeutic intervention in major neurodegenerative disease

SV Mangrulkar, NL Wankhede, MB Kale… - Neurotoxicity …, 2023 - Springer
… to target dysfunction of mitochondria in the treatment of neurodegenerative diseases, this
review … responses, spanning from energy generation to cell mortality. The careful regulation of …

3-Nitrotyrosine: a versatile oxidative stress biomarker for major neurodegenerative diseases

M Bandookwala, P Sengupta - International Journal of …, 2020 - Taylor & Francis
mitochondrial dysfunction and Nrf2 in response to OS in the cytoplasm in sALS patients. Overall
data from … for TDP-43-mediated cell death through a mechanism yet not fully established […

Neurodegenerative diseases associated with mitochondrial DNA mutations

OA Zhunina, NG Yabbarov, AV Grechko… - Current …, 2020 - ingentaconnect.com
Mitochondrial dysfunction and cell death in neurodegenerative diseases through
nitroxidative stress. Brain Res 2016; 1637: 34-55. http://dx.doi.org/10.1016/j.brainres.2016.02.016 …

Fundamental mechanisms of the cell death caused by nitrosative stress

F Wang, Q Yuan, F Chen, J Pang, C Pan… - Frontiers in Cell and …, 2021 - frontiersin.org
disorders affects cell death. This review focuses on the biochemistry of nitrosative stress, as
well as several new forms of cell death, and … , mitochondrial dysfunction, and cell membrane …

… -Dependent Signaling Mechanisms in Apoptotic Cell Death in Cardiovascular, Rheumatic, Kidney, and Neurodegenerative Diseases and Mental Disorders

S Rodkin, C Nwosu, A Sannikov, A Tyurin… - International Journal of …, 2023 - mdpi.com
… However, excess NO can be detrimental, causing cartilage degradation or inhibiting cartilage
matrix synthesis and causing mitochondrial dysfunction. There is a correlation between NO …

Resveratrol: A potential therapeutic natural polyphenol for neurodegenerative diseases associated with mitochondrial dysfunction

E Yadav, P Yadav, MMU Khan, HO Singh… - Frontiers in …, 2022 - frontiersin.org
… It showed that RES treatment to SH-SY5Y cells significantly prevented the cell death
initiated by rotenone via modulating autophagic induction and overall autophagic flux. Further …

Therapeutic strategies to ameliorate neuronal damage in epilepsy by regulating oxidative stress, mitochondrial dysfunction, and neuroinflammation

S Madireddy, S Madireddy - Brain sciences, 2023 - mdpi.com
… to an efflux of ions and mitochondrial molecules that ultimately cause cell death [73]. …
mitochondrial Ca 2+ levels have been observed during seizures [83]. An excess of mitochondrial

The redox language in neurodegenerative diseases: oxidative post-translational modifications by hydrogen peroxide

YM Lee, W He, YC Liou - Cell death & disease, 2021 - nature.com
… Moreover, mitochondrial dysfunction has been linked to various neurodegenerative diseases,
and … quality control (MQC); mitochondrial dysfunction can lead to cell death upon the …

Oxidative stress and mitochondrial dysfunction following traumatic brain injury: From mechanistic view to targeted therapeutic opportunities

B Hakiminia, B Alikiaii, F Khorvash… - Fundamental & …, 2022 - Wiley Online Library
… to the mitochondrial dysfunction, which results in the energy failure and neuronal cell death
[… Impaired mitophagy has been documented in neurodegenerative diseases [68] and TBI [69]…