Renal revascularization attenuates myocardial mitochondrial damage and improves diastolic function in pigs with metabolic syndrome and renovascular hypertension

RA Farahani, S Yu, CM Ferguson, XY Zhu… - Journal of …, 2022 - Springer
restoration of kidney function by PTRA ameliorates myocardial mitochondrial damage and
preserves cardiac functionmitochondrial protection by PTRA preserves cardiac structure and …

Renovascular hypertension induces myocardial mitochondrial damage, contributing to cardiac injury and dysfunction in pigs with metabolic syndrome

AA Nargesi, MC Farah, XY Zhu, L Zhang… - … of hypertension, 2021 - academic.oup.com
… cause of secondary hypertension and renal failure commonly … this sex-specific protection.
Our observations demonstrate … in Lean + RVH failed to restore membrane potential, it resulted …

Experimental renovascular disease induces endothelial cell mitochondrial damage and impairs endothelium-dependent relaxation of renal artery segments

AA Nargesi, XY Zhu, IM Saadiq… - … of hypertension, 2020 - academic.oup.com
… of swine renovascular disease (RVD) induce mitochondrial … secondary hypertension and
renal dysfunction characterized … Atherosclerotic RVD is prevalent in the elderly population …

Percutaneous transluminal renal angioplasty attenuates poststenotic kidney mitochondrial damage in pigs with renal artery stenosis and metabolic syndrome

RA Farahani, M Afarideh, XY Zhu… - Journal of cellular …, 2021 - Wiley Online Library
mitochondrial damage and improving renal function in … Renovascular disease (RVD) due
to atherosclerotic renal artery stenosis … We found that PTRA that successfully restored renal

Chronic kidney disease and left ventricular diastolic dysfunction (CKD-LVDD) alter cardiac expression of mitochondria-related genes in swine

AR Chade, R Sitz, TJ Kelty, E McCarthy, DL Tharp… - Translational …, 2024 - Elsevier
… bilateral renovascular disease (right renal artery, R; left renal … impacts kidney function as
CKD worsens cardiac function. … as well as mitochondrial-specific protection (eg, mitochondria-…

SS‐31, a Mitochondria‐Targeting Peptide, Ameliorates Kidney Disease

Y Zhu, M Luo, X Bai, J Li, P Nie, B Li… - Oxidative Medicine and …, 2022 - Wiley Online Library
… Afterward, using a swine atherosclerotic … effects by protecting renal cell mitochondria, restoring
renal AMP kinase … PTRA for severe hypertension and/or decreased renal function. These …

Kidney intrinsic mechanisms as novel targets in renovascular hypertension

A Eirin, AR Chade, LO Lerman - Hypertension, 2024 - Am Heart Assoc
… to restore renal function in swine atherosclerotic renal artery stenosis. Stem … Restoration of
mitochondrial cardiolipin attenuates cardiac … Phase 2a clinical trial of mitochondrial protection (…

Vasodilator reactive oxygen species ameliorate perturbed myocardial oxygen delivery in exercising swine with multiple comorbidities

RWA van Drie, J van de Wouw, LM Zandbergen… - Basic Research in …, 2024 - Springer
… (2) ET-receptor blockade restore microvascular function and … and reduced renal function in
female swine, as evidenced by … with (mitochondrial) ROS augment mitochondrial derived H 2 …

Tubular mitochondrial dysfunction, oxidative stress, and progression of chronic kidney disease

M Fontecha-Barriuso, AM Lopez-Diaz… - Antioxidants, 2022 - mdpi.com
mitochondria protected from IRI-AKI in rats and in swine, … mitochondrial biogenesis and
improved kidney function after … Elamipretide was renoprotective and restored the mitochondrial

Elamipretide mitigates ischemia-reperfusion injury in a swine model of hemorrhagic shock

N Patel, MA Johnson, N Vapniarsky… - Scientific Reports, 2023 - nature.com
… We sought to rescue mitochondrial function in a pig model of … circulating blood volume is
restored with transfusion and … lactate concentration and preserving renal function. Overall, the …