Mitochondrial reactive oxygen species as major effectors of antimicrobial immunity

E Shekhova - PLoS pathogens, 2020 - journals.plos.org
… At the same time, ROS are important intracellular mediators that drive the appropriate … leads
to the secretion of proinflammatory cytokines, including IL-1β, TNFα, and IL-6 [18]. Therefore, …

Targeting mitochondrial-derived reactive oxygen species in T cell-mediated autoimmune diseases

MD Chávez, HM Tse - Frontiers in immunology, 2021 - frontiersin.org
… RORγt that drive differentiation and proinflammatory responses… that mitochondrial-derived
reactive oxygen species (ROS) … of SOD3 suppressed proinflammatory cytokine production and …

Reactive oxygen species: drivers of physiological and pathological processes

J Checa, JM Aran - Journal of Inflammation research, 2020 - Taylor & Francis
… Moreover, mitochondria-derived ROS hold also a relevant … driving the secretion of mature
cytokines and pyroptosis, a … of pro-inflammatory cytokines such as several interleukins (IL-6, IL-…

Reactive oxygen species in macrophages: sources and targets

M Canton, R Sánchez-Rodríguez, I Spera… - Frontiers in …, 2021 - frontiersin.org
… activation, ROS generation and proinflammatory cytokine production in hepatic infiltrating …
mitochondrial ROS in macrophages. The signaling and damaging properties of ROS can drive

Mitochondrial damage-associated molecular patterns stimulate reactive oxygen species production in human microglia

M Nasi, A De Gaetano, E Bianchini, S De Biasi… - Molecular and Cellular …, 2020 - Elsevier
… cell surface and the production of pro-inflammatory cytokines and reactive oxygen species.
At the … secretion of tumor necrosis factor-α and interleukin-6. However, after stimulation with …

Mitochondrial reactive oxygen species in physiology and disease

S Antonucci, F Di Lisa, N Kaludercic - Cell Calcium, 2021 - Elsevier
… macrophages that drive the pro-inflammatory response [129], … by high glucose and pro-inflammatory
cytokines led to PTP … several mitochondrial processes, including ROS production

Mitochondrial reactive oxygen species: double-edged weapon in host defense and pathological inflammation during infection

P Silwal, JK Kim, YJ Kim, EK Jo - Frontiers in immunology, 2020 - frontiersin.org
… roles of mitochondrial reactive oxygen species (mtROS) … drives aerobic glycolysis and
reactive oxygen species (ROS) … of mtROS and proinflammatory cytokine expression with NLRP3 …

Mitochondrial reactive oxygen species and mitophagy: a complex and nuanced relationship

JH Schofield, ZT Schafer - Antioxidants & redox signaling, 2021 - liebertpub.com
Significance: Mitochondria represent a major source of intracellular reactive oxygen species
This is often a consequence of oxidative phosphorylation, which can produce ROS as a …

Mitochondrial Reactive Oxygen Species Regulate Immune Responses of Macrophages to Aspergillus fumigatus

R Hatinguais, A Pradhan, GD Brown… - Frontiers in …, 2021 - frontiersin.org
… 1, lowers the production of pro-inflammatory cytokines TNF-α and … is required to regulate
cytokine secretion by RET-associated … across the mitochondrial inner membrane drive electrons …

Mitofusin 2 in macrophages links mitochondrial ROS production, cytokine release, phagocytosis, autophagy, and bactericidal activity

J Tur, S Pereira-Lopes, T Vico, EA Marín, JP Munoz… - Cell reports, 2020 - cell.com
… and for the production of reactive oxygen species (ROS) upon pro-inflammatory activation.
Mfn2 deficiency specifically impairs the production of pro-inflammatory cytokines and nitric …