[PDF][PDF] Gemcitabine Resistance Elicits a Calcium Dependent Epigenetic Reprogramming in Pancreatic Cancer

AP Kutschat - 2021 - ediss.uni-goettingen.de
… of the transcription factor ΔNp63, while early development … The ISR is also triggered by PERK,
which phosphorylates … to restore calcium levels and increase its folding activity, GRP78 no …

The Role of the CDK8 Kinase Module in Maintaining Proteostasis

SD Willis - 2023 - search.proquest.com
… ATP in the cytosol is roughly 100 times faster[206, 207]. This … phosphorylation of their
regulatory domains [239]. Although this does not cause the destruction of these transcription factors

Cellular bioassays as a clinical tool for monitoring sex steroids

RA Lund - 2020 - ourarchive.otago.ac.nz
… a cellular response by diffusing into cells and binding to their … )), which upon activation,
operate as transcription factors and … the cell seeding density of T47D-ER cells for improved assay …

Tails of twists and turns: Using zebrafish to unravel neutrophil chromatin remodelling

SW Gaines - 2022 - etheses.whiterose.ac.uk
… of the proinflammatory transcription factor NF-κB and cytokine … T cell receptors (TCRs)
leading to activation of the T-cells. … , mitochondrial damage and increased mitogenic signalling. …

[PDF][PDF] The Acute Stress Response in the Brain: From Neuromodulation to Molecules

A Floriou Servou - 2020 - research-collection.ethz.ch
… the mouse LC while performing resting-state functional magnetic … showed an increase in
brain-wide connectivity, and a rapid … -induced changes in protein phosphorylation and in gene …

Effect of CLN3-loss-of-function on cellular metabolism and signalling

K Więciorek-Płuciennik - 2022 - ediss.uni-goettingen.de
… , transcription factor analysis … activity in CLN3 KO HEK under both normal and starvation
conditions. Likewise, we observed higher activity of S6K1 and mTORC1 in CLN3 KO HEK cells

Development of in vitro models to investigate the role of decidualisation, PDGF, and ho-1 on stromal–trophoblast interaction

IAR Alshalal - 2020 - etheses.bham.ac.uk
… and other factors on trophoblast expansion/invasion and identify decidual regulation of
HO-1 and PDGF activity in hESC. As defective hESC decidualisation causes infertility and …

Glycolipids in Parkinson's disease: beyond neuronal function

F Spanos, M Deleidi - FEBS Open Bio, 2023 - Wiley Online Library
… With regard to the involved molecular pathways, C2 ceramide inhibits the DNA binding and
activity of the pro… The knock-out of the protease SPPL3 in HAP1 cells caused enhanced HLA- …

[PDF][PDF] The involvement of the glucocorticoid receptor in regulating glucocorticoid ultradian rhythms: the role of the FK506-binding protein 51

JKB Gjerstad - 2020 - research-information.bris.ac.uk
… is that increased FKBP51 expression can cause a … Rapid non-genomic effects of glucocorticoids
in the brain and … of PKA and cAMP which results in the phosphorylation of ion-channels …

The roles of MCPyV early region in IL-17A-mediated inflammation and autophagy

J Miao - 2021 - theses.hal.science
Mitogen-activated protein kinases MCC … Since MCPyV T antigens specific intra-tumoral T
cell responses are … domain (LSD) that inhibits E3 ubiquitin ligase activity via interactions with …