L-Carnitine Production Through Biosensor-Guided Construction of the Neurospora crassa Biosynthesis Pathway in Escherichia coli

P Kugler, M Trumm, M Frese… - … in Bioengineering and …, 2021 - frontiersin.org
… assemble and optimize a four-step L-carnitine biosynthesis … fluorescence was detected
between the middle and end of the … trimethylammonium compounds such as L-carnitine, …

Development of a Biosensor for Crotonobetaine-CoA Ligase Screening Based on the Elucidation of Escherichia coli Carnitine Metabolism

P Kugler, D Fröhlich, VF Wendisch - ACS Synthetic Biology, 2020 - ACS Publications
… of studies of l-carnitine metabolism in Escherichia coli and its … as well as the other two
trimethylammonium (TMA) compounds, … of carnitine metabolism could prove helpful for optimizing

L-Carnitine Production in Pseudomonas fluorescens under phosphate starvation

A MacLean - 2021 - zone.biblio.laurentian.ca
… These optimizations are extremely important because … It is also tempting to speculate that
the trimethylammonium … Pyruvate, a main precursor of the TCA cycle can also act as a central

[HTML][HTML] Phosphate stress triggers the conversion of glycerol into l-carnitine in Pseudomonas fluorescens

A MacLean, F Legendre, S Tharmalingam… - Microbiological …, 2021 - Elsevier
… cycle and l-carnitine synthesis revealed a major metabolic … It is also tempting to speculate
that the trimethylammoniumOptimization of these biochemical processes can potentially …

Biochemical and structural elucidation of the L-carnitine degradation pathway of the human pathogen Acinetobacter baumannii

F Piskol, P Lukat, L Kaufhold, A Heger… - Frontiers in …, 2024 - frontiersin.org
central metabolite L-malate was hypothesized. Alternatively, … Overall, the metabolic
conversion of L-carnitine via malic … For pathway reconstitution experiments, the codon-optimized

Investigations of dimethylglycine, glycine betaine, and ectoine uptake by a betaine-carnitine-choline transporter family transporter with diverse substrate specificity in …

GJ Gregory, A Dutta, V Parashar… - Journal of Bacteriology, 2020 - Am Soc Microbiol
… in BCCTs that transport trimethylammonium compounds such as GB, l-carnitine, and γ-… (C
i S) models, respectively. The residues involved in the central binding pocket, cytoplasmic and …

Carnitine metabolism in the human gut: characterization of the two-component carnitine monooxygenase CntAB from Acinetobacter baumannii

M Massmig, E Reijerse, J Krausze, C Laurich… - Journal of Biological …, 2020 - ASBMB
… The gut microbiota makes use of dietary nutrients l-carnitine and … that prevented the formation
of TMA in mouse models. … The oligomeric architecture of Rieske oxygenases is of central

Exploring Acetate Metabolism: Genetically Characterizing Acetate Production and Acetate Utilization in the Fungal Pathogen Cryptococcus neoformans

R Catalan-Hurtado - 2024 - open.clemson.edu
… cerevisiae (S288c genetic background) and Escherichia coli (… coli with an emphasis on
enzymes of central metabolic … factor, melanin production, and the addition of 2 mM L-carnitine

[PDF][PDF] STRUCTURAL AND FUNCTIONAL STUDIES OF PROTEINS INVOLVED IN THE REGULATION OF FATTY ACID METABOLISM

D Zeļencova-Gopejenko - ebooks.rtu.lv
… possibilities of L-carnitine biosynthesis and FA metabolism for … hit-to-lead structure
optimization of the new medicines. … of the carboxyl- and trimethylammonium groups [10, 11]. Both …

Total volatile basic nitrogen and trimethylamine in muscle foods: Potential formation pathways and effects on human health

AEDA Bekhit, SG Giteru, BWB Holman… - … Reviews in Food …, 2021 - Wiley Online Library
… involved in the metabolism of choline, betaine, L-carnitine, … Choline is a beta-hydroxyethyl
trimethylammonium hydroxide … model was created using TVB-N content prediction models