[HTML][HTML] Hexahydrocannabinol (HHC) and Δ9-tetrahydrocannabinol (Δ9-THC) driven activation of cannabinoid receptor 1 results in biased intracellular signaling
O Durydivka, P Palivec, M Gazdarica, K Mackie… - Scientific Reports, 2024 - nature.com
… , with the aim to provide chronically ill patients relief using well-… levels of endogenous
extracellular signal-regulated kinases 1/2 … On the other hand, the allosteric modulator ORG27569 …
extracellular signal-regulated kinases 1/2 … On the other hand, the allosteric modulator ORG27569 …
[图书][B] Investigating Receptor-Mediated Effects of Select Cannabinoids on the Innate Inflammatory Response
M Preteroti - 2022 - search.proquest.com
… effects from modulation of psychoactivity to the immune response. Δ9-tetrahydrocannabinol
(… the phosphorylation and early activation of extracellular signal-regulated kinase ½ (ERK1/2)…
(… the phosphorylation and early activation of extracellular signal-regulated kinase ½ (ERK1/2)…
[HTML][HTML] CB1 Cannabinoid Receptors Stimulate Gβγ-GRK2-Mediated FAK Phosphorylation at Tyrosine 925 to Regulate ERK Activation Involving Neuronal Focal …
GD Dalton, ST Carney, JD Marshburn… - Frontiers in Cellular …, 2020 - frontiersin.org
… In both neuronal and non-neuronal cell types, modulation of CB 1 activity induced changes
… /Ras-dependent activation of extracellular signal-regulated kinase 2 (ERK2) phosphorylation …
… /Ras-dependent activation of extracellular signal-regulated kinase 2 (ERK2) phosphorylation …
Role of pregnenolone derivative AEF0117 on the regulation of CB1 signaling that mediates behavioral effects of THC
G Tomaselli - 2020 - theses.fr
… extracellular signal–regulated kinases FAAH … , acts as a positive allosteric modulator of
the CB1 receptor. … and its healing potential, Δ9tetrahydrocannabinol and cannabidiol, the two …
the CB1 receptor. … and its healing potential, Δ9tetrahydrocannabinol and cannabidiol, the two …
The effects of delta-9 tetrahydrocannabinol (THC) on granulosa cell viability, apoptosis, and gene expression
J Dufour - 2022 - atrium.lib.uoguelph.ca
… cortisol’s effects by modulating 11βHSDs, increasing GR … stem cells capable of supporting
long term oogenesis. During early … such as extracellular signal-regulated kinase (ERK1/2), …
long term oogenesis. During early … such as extracellular signal-regulated kinase (ERK1/2), …
[HTML][HTML] CB1 cannabinoid receptor signaling and biased signaling
LM Leo, ME Abood - Molecules, 2021 - mdpi.com
… action of certain biased allosteric modulators, we will analyze … use in the treatment of
acute and chronic pain. The analgesic … to modulate the activation of extracellular signal-regulated …
acute and chronic pain. The analgesic … to modulate the activation of extracellular signal-regulated …
[HTML][HTML] Cannabinoids Transmogrify Cancer Metabolic Phenotype via Epigenetic Reprogramming and a Novel CBD Biased G Protein-Coupled Receptor Signaling …
DA Bunsick, J Matsukubo, MR Szewczuk - Cancers, 2023 - mdpi.com
… The concept of epigenetic reprogramming predicts long-term … from the MAPK and extracellular
signal-regulated kinase (ERK) … , to our knowledge, biased modulation of NF-κB signaling …
signal-regulated kinase (ERK) … , to our knowledge, biased modulation of NF-κB signaling …
[HTML][HTML] Can hemp help? Low-THC cannabis and non-THC cannabinoids for the treatment of cancer
… factors, which together modulate oncogenic signalling and … occurrences in the adult life of
long-term ∆ 9 -THC cannabis … of the extracellular signal-regulated kinases, ERK and Akt [85…
long-term ∆ 9 -THC cannabis … of the extracellular signal-regulated kinases, ERK and Akt [85…
[HTML][HTML] Molecular mechanism of cannabinoids in cancer progression
… extracellular signal-regulated protein kinase activity [2]. CB1R has been discovered thanks to
Δ9-tetrahydrocannabinol … , and prefrontal cortex modulating several physiological functions …
Δ9-tetrahydrocannabinol … , and prefrontal cortex modulating several physiological functions …
Pharmacological potential of varinic-, minor-, and acidic phytocannabinoids
… phosphorylation of extracellular signal-regulated kinases (… that CBD is an allosteric modulator
of cannabinoid receptors. … published in 1973 on a chronic-administration study using CBN […
of cannabinoid receptors. … published in 1973 on a chronic-administration study using CBN […