Cannabinoids reduce extracellular vesicle release from HIV-1 infected myeloid cells and inhibit viral transcription

C DeMarino, M Cowen, P Khatkar, B Cotto… - Cells, 2022 - mdpi.com
… Cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC), the … cannabinoid CBD as a potential
EV-modulator (Figure 1). The … between the extracellular signal-regulated protein kinases 1 …

Effect of Cannabidiol on ERK and CREB Signaling in Neuronal and Microglia Cells

TK Mistry - 2022 - search.proquest.com
… We hypothesize that CBD modulate the ERK and CREB … , but he did not separate (Δ9-tetrahydrocannabinol)
Δ9-THC. Δ9-… kinases), and ERK (Extracellular Signal-Regulated Kinase) is a …

Extracellular Matrix (ECM)

M Papanicolaou, TR Cox - Encyclopedia of Molecular Pharmacology, 2022 - Springer
… , chronic renal failure, cyclical vomiting syndrome, pregnancy sickness). Drugs which can
modulate … of the pharmacological effects of Δ9- tetrahydrocannabinol (THC) and synthetic …

New insights into peptide cannabinoids: structure, biosynthesis and signaling

A Riquelme-Sandoval, CO de Sá-Ferreira… - Frontiers in …, 2020 - frontiersin.org
… on their activation and modulation of cannabinoid receptors. … long-term plasticity, CB1
modulates the levels of intracellularsignal regulated kinase [ERK]). CB1 and CB2 activation of the …

Endocannabinoid system and tumour microenvironment: New intertwined connections for anticancer approaches

M Iozzo, G Sgrignani, G Comito, P Chiarugi… - Cells, 2021 - mdpi.com
… relevant findings of the tumour response to ECS modulation, encouraging a more in-depth …
kinase (PKA) activity [67]. Moreover, the block of the extracellular signal regulated kinase (…

Cannabinoid control of hippocampal functions: the where matters

A Robledo‐Menendez, M Vella, P Grandes… - The FEBS …, 2022 - Wiley Online Library
… on the CB1 receptor modulation of hippocampal function. … activated protein kinases/extracellular
signal-regulated kinase (… long-term potentiation (LTP) or weaken it through long-term

Serotonin 2A receptors and cannabinoids

I Ibarra-Lecue, R Diez-Alarcia, L Urigüen - Progress in Brain Research, 2021 - Elsevier
… To date, the focus has redirected toward the understanding of different serotonin receptors,
through a demonstration of its versatile pharmacology and synergy with different modulators. …

Acidic cannabinoids suppress proinflammatory cytokine release by blocking store-operated calcium entry

M Faouzi, C Wakano, MK Monteilh-Zoller… - Function, 2022 - academic.oup.com
… , a persistent and resolute response leads to chronic … Our results confirm that CBGA
modulates SOCE in T cells … that target the pro-inflammatory cascade in immune cells. Our results …

[PDF][PDF] Assessing Toll-like receptor 3/4 signalling as a phytocannabinoid target in immune cells

JMK Fitzpatrick - 2020 - tara.tcd.ie
… TLR3 and TLR4 are differentially modulated by Δ9-tetrahydrocannabinol and cannabidiol in
… - European medicines agency ERK - extracellular signal-regulated kinase FAAH - fatty acid …

Molecular mechanism and cannabinoid pharmacology

LD Schurman, D Lu, DA Kendall, AC Howlett… - … Use Disorders: From …, 2020 - Springer
… nervous system, where they modulate neurotransmitter release. In … The FDA recently approved
CBD to treat severe forms of … For example, extracellular signal-regulated kinase (ERK)1 …