[HTML][HTML] Enhancing therapeutic approaches for melanoma patients targeting epigenetic modifiers

M Gracia-Hernandez, Z Munoz, A Villagra - Cancers, 2021 - mdpi.com
Epigenetic alterations can also lead to immune evasion and … to treat patients that do not
respond or become resistant to first… molecules in melanoma cells and decreased tumor growth in …

[HTML][HTML] Molecular characterization of the clinical and tumor immune microenvironment signature of 5-methylcytosine-related regulators in non-small cell lung cancer

T Liu, L Guo, G Liu, X Hu, X Li, J Zhang… - Frontiers in Cell and …, 2021 - frontiersin.org
… For background correction and normalization, the Robust … of immunotherapy outcomes.
However, the survival analysis … Epigenetic alterations are associated extensively with the …

Phenotypic characterization of tumor CTLA-4 expression in melanoma tissues and its possible role in clinical response to Ipilimumab

MP Pistillo, R Carosio, F Grillo, V Fontana… - Clinical …, 2020 - Elsevier
Molecular and epigenetic features of melanomas and tumor immune microenvironment
linked to durable remission to ipilimumab-based immunotherapy in metastatic patients

[HTML][HTML] Genetic and epigenetic biomarkers of immune checkpoint blockade response

Q Xiao, A Nobre, P Piñeiro… - Journal of clinical …, 2020 - mdpi.com
… of JAK family members render melanoma resistant to IFN-γ … be related to progressive disease
in melanoma patients. … of the anti-tumor immune reactivation could be related to the post-…

[HTML][HTML] Molecular immunotherapy: promising approach to treat metastatic colorectal cancer by targeting resistant cancer cells or cancer stem cells

S Forster, R Radpour - Frontiers in oncology, 2020 - frontiersin.org
… response, they are associated with virtually no activity in patients with pMMR/… remission
rates in metastatic CRC (60). Recently, modern molecular analysis has shown that melanoma

Lower expression of GBP2 associated with less immune cell infiltration and poor prognosis in skin cutaneous melanoma (SKCM)

S Zhang, K Chen, Z Zhao, X Zhang, L Xu… - … of Immunotherapy, 2022 - journals.lww.com
… of the immune microenvironment, 7 and tumor antigens can … molecular markers of immune
infiltration cells and negatively … modifications, which can be as a crucial epigenetic regulator of …

Mechanisms of response and resistance to combined decitabine and ipilimumab for advanced myeloid disease

L Penter, Y Liu, JO Wolff, L Yang, L Taing, A Jhaveri… - Blood, 2023 - ashpublications.org
… cutis samples from patients with durable remission after ipilimumab … , bladder cancer, and
metastatic melanoma, recently … of response to ipilimumab-based therapy. Consistent with …

[HTML][HTML] … profiles differ in responders versus non-responders to anti-PD-1 immune checkpoint inhibitors in patients with advanced and metastatic head and neck …

AM Starzer, G Heller, E Tomasich… - … for Immunotherapy of …, 2022 - ncbi.nlm.nih.gov
… genes involved in cancer-related molecular pathways. Over-… potential of durable responses,
immune-related side effects … Due to clinical indications in our patients the first radiological …

Network for biomarker immunoprofiling for cancer immunotherapy: cancer immune monitoring and analysis centers and cancer immunologic data commons (CIMAC …

HX Chen, M Song, HT Maecker, S Gnjatic… - Clinical Cancer …, 2021 - AACR
… Furthermore, biomarkers to predict immune-related adverse … measures epigenetic changes
in sorted specific immune cell … prevention, and treatment of melanoma using PD-L1 isoforms …

[HTML][HTML] Response to immune Checkpoint inhibitors is affected by Deregulations in the antigen presentation machinery: A systematic review and meta-analysis

M Rasmussen, JA Durhuus, M Nilbert… - Journal of Clinical …, 2022 - mdpi.com
… (ipilimumab) drugs where molecular investigations including the following … malignant
melanoma and an associated lung metastasis … HLA class I can be epigenetically downregulation …