[HTML][HTML] Ovarian aging: molecular mechanisms and medical management

J Tesarik, M Galán-Lázaro… - … journal of molecular …, 2021 - mdpi.com
… secondary structure of the mitochondrial genome; certain patterns of the global secondary
structure of the human single-stranded heavy chain of mtDNA make the DNA molecule more …

[HTML][HTML] Human granulosa cells—stemness properties, molecular cross-talk and follicular angiogenesis

C Dompe, M Kulus, K Stefańska, W Kranc, B Chermuła… - Cells, 2021 - mdpi.com
… appearance varies in terms of the number of somatic cell layers and their cellular structure. …
indicating that germline stem cells were absent in adult ovaries [37]. This would contradict the …

[HTML][HTML] The stemness of human ovarian granulosa cells and the role of resveratrol in the differentiation of MSCs—a review based on cellular and molecular …

M Jozkowiak, G Hutchings, M Jankowski, K Kulcenty… - Cells, 2020 - mdpi.com
… Steroidogenesis in the adult ovary is a complex, … structure-activity relationship studies have
revealed that methoxy substitution of hydroxyl groups increases the stability of the molecule

[HTML][HTML] The molecular regulation in the pathophysiology in ovarian aging

CJ Li, LT Lin, HW Tsai, CU Chern, ZH Wen… - Aging and …, 2021 - ncbi.nlm.nih.gov
… factors of aging-induced ovarian insufficiency based on its clinical … molecular mechanisms
and potential targets to provide novel approaches for the effective improvement of ovarian

Genetic insights into biological mechanisms governing human ovarian ageing

KS Ruth, FR Day, J Hussain, A Martínez-Marchal… - Nature, 2021 - nature.com
… Here we identify 290 genetic determinants of ovarian ageing, … an equivalent risk of premature
ovarian insufficiency to those … the life-course to shape the ovarian reserve and its rate of …

[HTML][HTML] The ovarian stroma as a new frontier

HM Kinnear, CE Tomaszewski, FL Chang… - …, 2020 - rep.bioscientifica.com
ovarian environment to maintain the spherical structure of follicles and allow for their expansion;
however, these systems are lacking the biological functionality of ECM and the ability to …

[HTML][HTML] Molecular features of polycystic ovary syndrome revealed by transcriptome analysis of oocytes and cumulus cells

J Li, H Chen, M Gou, C Tian, H Wang… - Frontiers in cell and …, 2021 - frontiersin.org
… All participants underwent controlled ovarian stimulation using the GnRH antagonist
protocols with the recombinant human follicle-stimulating hormone (rhFSH) and intracytoplasmic …

[HTML][HTML] Low molecular weight hyaluronan induces an inflammatory response in ovarian stromal cells and impairs gamete development in vitro

JE Rowley, F Amargant, LT Zhou, A Galligos… - … journal of molecular …, 2020 - mdpi.com
… , we compared gene expression patterns in whole ovaries and ovarian stromal husks in
reproductively old mice … (6) Mature eosinophils are recruited into ovarian stroma in response to …

[HTML][HTML] The signaling pathways involved in ovarian follicle development

L Li, X Shi, Y Shi, Z Wang - Frontiers in Physiology, 2021 - frontiersin.org
molecular mechanism of ovarian development is complicated, and understanding the signaling
pathways in ovarian … from Foxo3 –/– knockout mice appeared more mature than that of …

Prenatal exposure to propylparaben at human-relevant doses accelerates ovarian aging in adult mice

M Li, S Zhou, Y Wu, Y Li, W Yan, Q Guo, Y Xi… - Environmental …, 2021 - Elsevier
… endocrine disruptors widely used in pharmaceuticals and cosmetics, have been shown to
cause a … molecular mechanisms underlying the adverse impacts of PrP on the offspring mice. …